Specialized plasma membrane domains called coated pits are key regulatory sites in glycoprotein biology. There, glycoproteins destined for endocytosis or receptors which are themselves glycoproteins are clustered and processed for internalization. The structural components and the regulatory mechanisms active at coated pits are the subject of intense investigation. Studies with the asialoglycoprotein (ASGP) receptor have elucidated many of these mechanisms, such as a sorting signal responsible for rapid internalization and the intracellular compartments involved in receptor trafficking. Recent data with this receptor suggest that tyrosine kinase activity specifically influences the rate of receptor internalization. A model of glycoprotein endocytosis is thus suggested where, in addition to their role in signal transduction, tyrosine kinases function in the regulation of the early endocytic pathway.
ASJC Scopus subject areas
- Organic Chemistry