Regulatory function of mitochondria in lipogenesis

Robert Harris, Michael C. Leland, Joan Munroe Mahoney, James P. Mapes

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A cell-free system, consisting of particle-free rat liver cytoplasm plus purified mitochondria, was used to study the synthesis of fatty acid from14C-U-alanine. Incorporation of label into lipid was dependent upon the presence of both cytoplasm and mitochondria. However, the metabolic state of the animal, prior to sacrifice, determined the capacity of various mitochondrial preparations to reconstitute the system. Mitochondria prepared from the livers of starved, fat-fed, or alloxan-diabetic rats failed to support fatty acid synthesis to the same extent as mitochondria prepared from control animals. Likewise, less14CO2 was produced in the system reconstituted with liver mitochondria prepared from starved rats. Possible mechanisms are discussed.

Original languageEnglish
Pages (from-to)711-716
Number of pages6
JournalLipids
Volume8
Issue number12
DOIs
StatePublished - Dec 1973

Fingerprint

Lipogenesis
Mitochondria
lipogenesis
mitochondria
Liver Mitochondrion
Liver
Cytoplasm
Fatty Acids
Rats
Alloxan
Cell-Free System
liver
rats
Animals
Alanine
cytoplasm
fatty acids
cell free system
alloxan
Fats

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Food Science

Cite this

Harris, R., Leland, M. C., Mahoney, J. M., & Mapes, J. P. (1973). Regulatory function of mitochondria in lipogenesis. Lipids, 8(12), 711-716. https://doi.org/10.1007/BF02531837

Regulatory function of mitochondria in lipogenesis. / Harris, Robert; Leland, Michael C.; Mahoney, Joan Munroe; Mapes, James P.

In: Lipids, Vol. 8, No. 12, 12.1973, p. 711-716.

Research output: Contribution to journalArticle

Harris, R, Leland, MC, Mahoney, JM & Mapes, JP 1973, 'Regulatory function of mitochondria in lipogenesis', Lipids, vol. 8, no. 12, pp. 711-716. https://doi.org/10.1007/BF02531837
Harris, Robert ; Leland, Michael C. ; Mahoney, Joan Munroe ; Mapes, James P. / Regulatory function of mitochondria in lipogenesis. In: Lipids. 1973 ; Vol. 8, No. 12. pp. 711-716.
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