Regulatory mechanisms that control mitotic kinesins

Amber L. Yount, Hailing Zong, Claire Walczak

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

During mitosis, the mitotic spindle is assembled to align chromosomes at the spindle equator in metaphase, and to separate the genetic material equally to daughter cells in anaphase. The spindle itself is a macromolecular machine composed of an array of dynamic microtubules and associated proteins that coordinate the diverse events of mitosis. Among the microtubule associated proteins are a plethora of molecular motor proteins that couple the energy of ATP hydrolysis to force production. These motors, including members of the kinesin superfamily, must function at the right time and in the right place to insure the fidelity of mitosis. Misregulation of mitotic motors in disease states, such as cancer, underlies their potential utility as targets for antitumor drug development and highlights the importance of understanding the molecular mechanisms for regulating their function. Here, we focus on recent progress about regulatory mechanisms that control the proper function of mitotic kinesins and highlight new findings that lay the path for future studies.

Original languageEnglish (US)
Pages (from-to)70-77
Number of pages8
JournalExperimental Cell Research
Volume334
Issue number1
DOIs
StatePublished - May 15 2015

Fingerprint

Kinesin
Mitosis
Microtubule-Associated Proteins
Molecular Motor Proteins
Anaphase
Spindle Apparatus
Metaphase
Antineoplastic Agents
Hydrolysis
Chromosomes
Adenosine Triphosphate
Genes
Neoplasms

ASJC Scopus subject areas

  • Cell Biology

Cite this

Regulatory mechanisms that control mitotic kinesins. / Yount, Amber L.; Zong, Hailing; Walczak, Claire.

In: Experimental Cell Research, Vol. 334, No. 1, 15.05.2015, p. 70-77.

Research output: Contribution to journalArticle

Yount, Amber L. ; Zong, Hailing ; Walczak, Claire. / Regulatory mechanisms that control mitotic kinesins. In: Experimental Cell Research. 2015 ; Vol. 334, No. 1. pp. 70-77.
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