Relation of JC virus DNA in the cerebrospinal fluid to survival in acquired immunodeficiency syndrome patients with biopsy-proven progressive multifocal leukoencephalopathy

Constantin Yiannoutsos, Eugene O. Major, Blanche Curfman, Peter N. Jensen, Maneth Gravell, Jean Hou, David B. Clifford, Colin D. Hall

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

The detection and semiquantitation of JC virus (JCV) DNA in cerebrospinal fluid (CSF) is prognostic of survival and is a marker of the course of progressive multifocal leukoencephalopathy (PML). CSF samples from 15 acquired immunodeficiency syndrome (AIDS) patients with biopsy-proven PML were analyzed by semiquantitative polymerase chain reaction (PCR). A low JCV burden was predictive of longer survival compared with a high JCV burden (median survival from entry, 24 [2-63] vs 7.6 [4-17] weeks). Further analyses indicated a possible threshold of 50 to 100 copies/μl separating high- and moderate-risk cases. Patients with a JCV load below this level survived longer than those with a JCV load above it.

Original languageEnglish (US)
Pages (from-to)816-821
Number of pages6
JournalAnnals of Neurology
Volume45
Issue number6
DOIs
StatePublished - 1999
Externally publishedYes

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JC Virus
Progressive Multifocal Leukoencephalopathy
Cerebrospinal Fluid
Acquired Immunodeficiency Syndrome
Biopsy
Survival
DNA
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Relation of JC virus DNA in the cerebrospinal fluid to survival in acquired immunodeficiency syndrome patients with biopsy-proven progressive multifocal leukoencephalopathy. / Yiannoutsos, Constantin; Major, Eugene O.; Curfman, Blanche; Jensen, Peter N.; Gravell, Maneth; Hou, Jean; Clifford, David B.; Hall, Colin D.

In: Annals of Neurology, Vol. 45, No. 6, 1999, p. 816-821.

Research output: Contribution to journalArticle

Yiannoutsos, Constantin ; Major, Eugene O. ; Curfman, Blanche ; Jensen, Peter N. ; Gravell, Maneth ; Hou, Jean ; Clifford, David B. ; Hall, Colin D. / Relation of JC virus DNA in the cerebrospinal fluid to survival in acquired immunodeficiency syndrome patients with biopsy-proven progressive multifocal leukoencephalopathy. In: Annals of Neurology. 1999 ; Vol. 45, No. 6. pp. 816-821.
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AU - Gravell, Maneth

AU - Hou, Jean

AU - Clifford, David B.

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