Relation of Proliferative Activity to Survival in Patients with Advanced Germ Cell Cancer

George W. Sledge, John N. Eble, Bruce J. Roth, Beth P. Wuhrman, Naomi Fineberg, Lawrence H. Einhorn

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Patients with advanced disseminated germ cell tumors of the testis, retroperitoneum, and mediastinum have impaired survival compared to other patients with disseminated germ cell tumors having less bulky metastatic disease. Among patients with advanced disseminated germ cell tumors, we currently lack adequate predictors of long-term survival. Flow cytometric analysis of the paraffin-embedded, formalin-fixed tumor blocks of 50 of these patients suggests that proliferative activity is significantly correlated with survival (p < 0.001) in multivariate analysis. Log (beta-human chorionic gonadotropin) is the only other useful predictor of long-term survival in multivariate analysis of prognostic factors in this group of patients. Flow cytometric DNA analysis may be useful in predicting survival in patients with advanced disseminated germ cell tumors.

Original languageEnglish (US)
Pages (from-to)3864-3868
Number of pages5
JournalCancer Research
Volume48
Issue number13
StatePublished - 1988

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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