Relationship among clinical factors in childhood intermittent exotropia

Pediatric Eye Disease Investigator Group

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose To determine the relationships between stereoacuity, control of exotropia, and angle of deviation in children with intermittent exotropia (IXT). Methods Data collected for 652 participants 3 to <11 years of age with IXT meeting eligibility criteria for enrollment into one of two multicenter, randomized clinical trials were used to evaluate relationships between stereoacuity, control, and angle of deviation at enrollment. Results Any level of stereoacuity and angle of deviation could be accompanied by any level of control. Worse distance exotropia control was weakly associated with poorer distance stereoacuity (R = 0.26; 99% CI, 0.17-0.36) and larger angles of deviation at distance (R = 0.27; 99% CI, 0.17-0.36). Worse near exotropia control was weakly associated with poorer near stereoacuity (R = 0.17; 99% CI, 0.07-0.27) and moderately associated with larger angles of deviation at near (R = 0.37; 99% CI, 0.28-0.45). There was no association between stereoacuity and angle of deviation at distance (R = 0.07; 99% CI, −0.03 to 0.17) or at near (R = 0.02; 99% CI, −0.08 to 0.12). Conclusions Although weak and moderate associations were found between stereoacuity, control, and angle of deviation, a child may exhibit any combination of stereoacuity, control, and angle of deviation. The specific roles of control, stereoacuity, and angle of deviation in the diagnosis, management, and pathogenesis of IXT are unclear, and each appears to yield somewhat independent information. [Figure presented]

Original languageEnglish (US)
Pages (from-to)268-273
Number of pages6
JournalJournal of AAPOS
Volume21
Issue number4
DOIs
StatePublished - Aug 1 2017
Externally publishedYes

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Exotropia
Randomized Controlled Trials

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Ophthalmology

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Relationship among clinical factors in childhood intermittent exotropia. / Pediatric Eye Disease Investigator Group.

In: Journal of AAPOS, Vol. 21, No. 4, 01.08.2017, p. 268-273.

Research output: Contribution to journalArticle

Pediatric Eye Disease Investigator Group. / Relationship among clinical factors in childhood intermittent exotropia. In: Journal of AAPOS. 2017 ; Vol. 21, No. 4. pp. 268-273.
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title = "Relationship among clinical factors in childhood intermittent exotropia",
abstract = "Purpose To determine the relationships between stereoacuity, control of exotropia, and angle of deviation in children with intermittent exotropia (IXT). Methods Data collected for 652 participants 3 to <11 years of age with IXT meeting eligibility criteria for enrollment into one of two multicenter, randomized clinical trials were used to evaluate relationships between stereoacuity, control, and angle of deviation at enrollment. Results Any level of stereoacuity and angle of deviation could be accompanied by any level of control. Worse distance exotropia control was weakly associated with poorer distance stereoacuity (R = 0.26; 99{\%} CI, 0.17-0.36) and larger angles of deviation at distance (R = 0.27; 99{\%} CI, 0.17-0.36). Worse near exotropia control was weakly associated with poorer near stereoacuity (R = 0.17; 99{\%} CI, 0.07-0.27) and moderately associated with larger angles of deviation at near (R = 0.37; 99{\%} CI, 0.28-0.45). There was no association between stereoacuity and angle of deviation at distance (R = 0.07; 99{\%} CI, −0.03 to 0.17) or at near (R = 0.02; 99{\%} CI, −0.08 to 0.12). Conclusions Although weak and moderate associations were found between stereoacuity, control, and angle of deviation, a child may exhibit any combination of stereoacuity, control, and angle of deviation. The specific roles of control, stereoacuity, and angle of deviation in the diagnosis, management, and pathogenesis of IXT are unclear, and each appears to yield somewhat independent information. [Figure presented]",
author = "{Pediatric Eye Disease Investigator Group} and Rosanne Superstein and Dean, {Trevano W.} and Holmes, {Jonathan M.} and Chandler, {Danielle L.} and Cotter, {Susan A.} and Wallace, {David K.} and Melia, {B. Michele} and Kraker, {Raymond T.} and Weaver, {R. Grey} and Mohney, {Brian G.} and Donahue, {Sean P.} and Birch, {Eileen E.}",
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T1 - Relationship among clinical factors in childhood intermittent exotropia

AU - Pediatric Eye Disease Investigator Group

AU - Superstein, Rosanne

AU - Dean, Trevano W.

AU - Holmes, Jonathan M.

AU - Chandler, Danielle L.

AU - Cotter, Susan A.

AU - Wallace, David K.

AU - Melia, B. Michele

AU - Kraker, Raymond T.

AU - Weaver, R. Grey

AU - Mohney, Brian G.

AU - Donahue, Sean P.

AU - Birch, Eileen E.

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Purpose To determine the relationships between stereoacuity, control of exotropia, and angle of deviation in children with intermittent exotropia (IXT). Methods Data collected for 652 participants 3 to <11 years of age with IXT meeting eligibility criteria for enrollment into one of two multicenter, randomized clinical trials were used to evaluate relationships between stereoacuity, control, and angle of deviation at enrollment. Results Any level of stereoacuity and angle of deviation could be accompanied by any level of control. Worse distance exotropia control was weakly associated with poorer distance stereoacuity (R = 0.26; 99% CI, 0.17-0.36) and larger angles of deviation at distance (R = 0.27; 99% CI, 0.17-0.36). Worse near exotropia control was weakly associated with poorer near stereoacuity (R = 0.17; 99% CI, 0.07-0.27) and moderately associated with larger angles of deviation at near (R = 0.37; 99% CI, 0.28-0.45). There was no association between stereoacuity and angle of deviation at distance (R = 0.07; 99% CI, −0.03 to 0.17) or at near (R = 0.02; 99% CI, −0.08 to 0.12). Conclusions Although weak and moderate associations were found between stereoacuity, control, and angle of deviation, a child may exhibit any combination of stereoacuity, control, and angle of deviation. The specific roles of control, stereoacuity, and angle of deviation in the diagnosis, management, and pathogenesis of IXT are unclear, and each appears to yield somewhat independent information. [Figure presented]

AB - Purpose To determine the relationships between stereoacuity, control of exotropia, and angle of deviation in children with intermittent exotropia (IXT). Methods Data collected for 652 participants 3 to <11 years of age with IXT meeting eligibility criteria for enrollment into one of two multicenter, randomized clinical trials were used to evaluate relationships between stereoacuity, control, and angle of deviation at enrollment. Results Any level of stereoacuity and angle of deviation could be accompanied by any level of control. Worse distance exotropia control was weakly associated with poorer distance stereoacuity (R = 0.26; 99% CI, 0.17-0.36) and larger angles of deviation at distance (R = 0.27; 99% CI, 0.17-0.36). Worse near exotropia control was weakly associated with poorer near stereoacuity (R = 0.17; 99% CI, 0.07-0.27) and moderately associated with larger angles of deviation at near (R = 0.37; 99% CI, 0.28-0.45). There was no association between stereoacuity and angle of deviation at distance (R = 0.07; 99% CI, −0.03 to 0.17) or at near (R = 0.02; 99% CI, −0.08 to 0.12). Conclusions Although weak and moderate associations were found between stereoacuity, control, and angle of deviation, a child may exhibit any combination of stereoacuity, control, and angle of deviation. The specific roles of control, stereoacuity, and angle of deviation in the diagnosis, management, and pathogenesis of IXT are unclear, and each appears to yield somewhat independent information. [Figure presented]

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