Relationship between dietary carbohydrates intake and circulating sex hormone-binding globulin levels in postmenopausal women

Mengna Huang, Jinjie Liu, Xiaochen Lin, Atsushi Goto, Yiqing Song, Lesley F. Tinker, Kei hang Katie Chan, Simin Liu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Low circulating levels of sex hormone-binding globulin (SHBG) have been shown to be a direct and strong risk factor for type 2 diabetes, cardiovascular diseases, and hormone-dependent cancers, although the relationship between various aspects of dietary carbohydrates and SHBG levels remains unexplored in population studies. Methods: Among postmenopausal women with available SHBG measurements at baseline (n=11159) in the Women's Health Initiative, a comprehensive assessment was conducted of total dietary carbohydrates, glycemic load (GL), glycemic index (GI), fiber, sugar, and various carbohydrate-abundant foods in relation to circulating SHBG levels using multiple linear regressions adjusting for potential covariates. Linear trend was tested across quartiles of dietary variables. Benjamini and Hochberg's procedure was used to calculate the false discovery rate for multiple comparisons. Results: Higher dietary GL and GI (both based on total and available carbohydrates) and a higher intake of sugar and sugar-sweetened beverages were associated with lower circulating SHBG concentrations (all P trend< 0.05; Q -values= 0.04,0.01, 0.07, 0.10, 0.01, and <0.0001, respectively). In contrast, women with a greater intake of dietary fiber tended to have elevated SHBG levels (P trend=0.01, Q -value=0.04). There was no significant association between total carbohydrates or other carbohydrate-abundant foods and SHBG concentrations. Conclusions: The findings suggest that low GL or GI diets with low sugar and high fiber content may be associated with higher serum SHBG concentrations among postmenopausal women. Future studies investigating whether lower GL or GI diets increase SHBG concentrations are warranted.

Original languageEnglish (US)
JournalJournal of Diabetes
DOIs
StateAccepted/In press - Jan 1 2017

Fingerprint

Dietary Carbohydrates
Sex Hormone-Binding Globulin
Glycemic Index
Carbohydrates
Diet
Serum Globulins
Food
Beverages
Dietary Fiber
Women's Health
Type 2 Diabetes Mellitus
Linear Models
Cardiovascular Diseases
Hormones

Keywords

  • Dietary carbohydrates
  • Glycemic index
  • Glycemic load
  • Sex hormone binding globulin (SHBG)
  • Type 2 diabetes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Relationship between dietary carbohydrates intake and circulating sex hormone-binding globulin levels in postmenopausal women. / Huang, Mengna; Liu, Jinjie; Lin, Xiaochen; Goto, Atsushi; Song, Yiqing; Tinker, Lesley F.; Chan, Kei hang Katie; Liu, Simin.

In: Journal of Diabetes, 01.01.2017.

Research output: Contribution to journalArticle

Huang, Mengna ; Liu, Jinjie ; Lin, Xiaochen ; Goto, Atsushi ; Song, Yiqing ; Tinker, Lesley F. ; Chan, Kei hang Katie ; Liu, Simin. / Relationship between dietary carbohydrates intake and circulating sex hormone-binding globulin levels in postmenopausal women. In: Journal of Diabetes. 2017.
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abstract = "Background: Low circulating levels of sex hormone-binding globulin (SHBG) have been shown to be a direct and strong risk factor for type 2 diabetes, cardiovascular diseases, and hormone-dependent cancers, although the relationship between various aspects of dietary carbohydrates and SHBG levels remains unexplored in population studies. Methods: Among postmenopausal women with available SHBG measurements at baseline (n=11159) in the Women's Health Initiative, a comprehensive assessment was conducted of total dietary carbohydrates, glycemic load (GL), glycemic index (GI), fiber, sugar, and various carbohydrate-abundant foods in relation to circulating SHBG levels using multiple linear regressions adjusting for potential covariates. Linear trend was tested across quartiles of dietary variables. Benjamini and Hochberg's procedure was used to calculate the false discovery rate for multiple comparisons. Results: Higher dietary GL and GI (both based on total and available carbohydrates) and a higher intake of sugar and sugar-sweetened beverages were associated with lower circulating SHBG concentrations (all P trend< 0.05; Q -values= 0.04,0.01, 0.07, 0.10, 0.01, and <0.0001, respectively). In contrast, women with a greater intake of dietary fiber tended to have elevated SHBG levels (P trend=0.01, Q -value=0.04). There was no significant association between total carbohydrates or other carbohydrate-abundant foods and SHBG concentrations. Conclusions: The findings suggest that low GL or GI diets with low sugar and high fiber content may be associated with higher serum SHBG concentrations among postmenopausal women. Future studies investigating whether lower GL or GI diets increase SHBG concentrations are warranted.",
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