Determinants of LA dilation In patients (pis) with hypertension (HTN) have not been well evaluated. We studied the relationship between LV diastolic filling indices and left atrlal (LA) size In 122 HTN pts and 60 healthy controls. All pts were in sinus rhythm without evidence of structural heart disease. LA size, peak early mitral inflow velocity. (E), peak late mitral inflow velocity (A). E/A ratio (E/A), mitral inflow deceleration time (DT), Isovolumlc relaxation time (VRT) and LV mass index were obtained using standard methods. When diastolic filling Indices between pts with dilated and normal LA were compared, statistically significant difference was observed in: A (77.3 vs 61.3 cm/s p<0.0001), E/A (1.03 vs 1.20 P=0.003), IVRT (94.2 vs 90.9 ms P-0.013) and DT (197.2 vs 183.4 ms P =0.01). Pts with HTN had a higher proportion of enlarged (>4 cm) LA (61 vs 12 p 0.0002). Age, sex. and heart rate were comparable In pts with HTN and controls. Among hypertensive pts 75% with dilated LA and 54% with normal LA had abnormal diastolic indices. There was no statistical difference in E/A, IVRT and DT between HTN pts with increased and normal LV mass index. By multivariate analysis peak A, DT, BSA, sex and LV mass index were shown to be independently associated with LA size (p<0.001). These data suggest that LA dilation is common among hypertensive pts and frequently accompanied by abnormal diastolic filling indices. Peak A, DT, BSA and LV mass Index are independently associated with LA sizes. This study indicates that LV diastolic dysfunction may play a role in the development of LA dilation in patients with hypertension.
|Original language||English (US)|
|Journal||Journal of Investigative Medicine|
|State||Published - Jan 1 1996|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)