Relationship between Na

K and Na:Na exchange by the sodium pump of skeletal muscle

Brian Kennedy, Paul De Weer

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

THE sodium pump can catalyse several modes of cation exchange (for example Na:K, Na:Na, and K:K), which have been characterised mainly in human red blood cells1-3, squid giant axon4-6, and frog skeletal muscle7-9. In all three tissues it seems that intracellular ADP levels determine the extent to which the pump can engage in Na:Na exchange 2,6,9,10. Yet, despite its obvious kinetic implications, the basic question of how the 'normal' Na:K exchange is affected by the appearance of ADP-induced Na:Na exchange, has not been answered. Here we present evidence that, in frog skeletal muscle, elevated intracellular ADP levels have little effect on pre-existing electrogenic Na:K exchange, but cause Na:Na exchange to appear in addition to ongoing Na:K exchange.

Original languageEnglish (US)
Pages (from-to)165-167
Number of pages3
JournalNature
Volume268
Issue number5616
DOIs
StatePublished - 1977
Externally publishedYes

Fingerprint

Sodium-Potassium-Exchanging ATPase
Adenosine Diphosphate
Skeletal Muscle
Anura
Decapodiformes
Cations

ASJC Scopus subject areas

  • General

Cite this

Relationship between Na : K and Na:Na exchange by the sodium pump of skeletal muscle. / Kennedy, Brian; De Weer, Paul.

In: Nature, Vol. 268, No. 5616, 1977, p. 165-167.

Research output: Contribution to journalArticle

@article{3f59ed08f01d4d6990590770be7035ee,
title = "Relationship between Na: K and Na:Na exchange by the sodium pump of skeletal muscle",
abstract = "THE sodium pump can catalyse several modes of cation exchange (for example Na:K, Na:Na, and K:K), which have been characterised mainly in human red blood cells1-3, squid giant axon4-6, and frog skeletal muscle7-9. In all three tissues it seems that intracellular ADP levels determine the extent to which the pump can engage in Na:Na exchange 2,6,9,10. Yet, despite its obvious kinetic implications, the basic question of how the 'normal' Na:K exchange is affected by the appearance of ADP-induced Na:Na exchange, has not been answered. Here we present evidence that, in frog skeletal muscle, elevated intracellular ADP levels have little effect on pre-existing electrogenic Na:K exchange, but cause Na:Na exchange to appear in addition to ongoing Na:K exchange.",
author = "Brian Kennedy and {De Weer}, Paul",
year = "1977",
doi = "10.1038/268165a0",
language = "English (US)",
volume = "268",
pages = "165--167",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "5616",

}

TY - JOUR

T1 - Relationship between Na

T2 - K and Na:Na exchange by the sodium pump of skeletal muscle

AU - Kennedy, Brian

AU - De Weer, Paul

PY - 1977

Y1 - 1977

N2 - THE sodium pump can catalyse several modes of cation exchange (for example Na:K, Na:Na, and K:K), which have been characterised mainly in human red blood cells1-3, squid giant axon4-6, and frog skeletal muscle7-9. In all three tissues it seems that intracellular ADP levels determine the extent to which the pump can engage in Na:Na exchange 2,6,9,10. Yet, despite its obvious kinetic implications, the basic question of how the 'normal' Na:K exchange is affected by the appearance of ADP-induced Na:Na exchange, has not been answered. Here we present evidence that, in frog skeletal muscle, elevated intracellular ADP levels have little effect on pre-existing electrogenic Na:K exchange, but cause Na:Na exchange to appear in addition to ongoing Na:K exchange.

AB - THE sodium pump can catalyse several modes of cation exchange (for example Na:K, Na:Na, and K:K), which have been characterised mainly in human red blood cells1-3, squid giant axon4-6, and frog skeletal muscle7-9. In all three tissues it seems that intracellular ADP levels determine the extent to which the pump can engage in Na:Na exchange 2,6,9,10. Yet, despite its obvious kinetic implications, the basic question of how the 'normal' Na:K exchange is affected by the appearance of ADP-induced Na:Na exchange, has not been answered. Here we present evidence that, in frog skeletal muscle, elevated intracellular ADP levels have little effect on pre-existing electrogenic Na:K exchange, but cause Na:Na exchange to appear in addition to ongoing Na:K exchange.

UR - http://www.scopus.com/inward/record.url?scp=0017372771&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017372771&partnerID=8YFLogxK

U2 - 10.1038/268165a0

DO - 10.1038/268165a0

M3 - Article

VL - 268

SP - 165

EP - 167

JO - Nature

JF - Nature

SN - 0028-0836

IS - 5616

ER -