Relationship between Na:K and Na:Na exchange by the sodium pump of skeletal muscle

Brian G. Kennedy, Paul De Weer

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

THE sodium pump can catalyse several modes of cation exchange (for example Na:K, Na:Na, and K:K), which have been characterised mainly in human red blood cells1-3, squid giant axon4-6, and frog skeletal muscle7-9. In all three tissues it seems that intracellular ADP levels determine the extent to which the pump can engage in Na:Na exchange 2,6,9,10. Yet, despite its obvious kinetic implications, the basic question of how the 'normal' Na:K exchange is affected by the appearance of ADP-induced Na:Na exchange, has not been answered. Here we present evidence that, in frog skeletal muscle, elevated intracellular ADP levels have little effect on pre-existing electrogenic Na:K exchange, but cause Na:Na exchange to appear in addition to ongoing Na:K exchange.

Original languageEnglish (US)
Pages (from-to)165-167
Number of pages3
JournalNature
Volume268
Issue number5616
DOIs
StatePublished - Dec 1 1977
Externally publishedYes

ASJC Scopus subject areas

  • General

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