Relationship between platelet monoamine oxidase B activity and alleles at the MAOB locus

A. Sule Girmen, John Baenziger, Gokhan S. Hotamisligil, Christine Konradi, Christo Shalish, Jack L. Sullivan, Xandra O. Breakefield

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Genetic variations in monoamine oxidase (MAO)-B activity have been proposed to have a contributory role in several neurologic and psychiatric diseases. Variations in activity could affect rates of degradation of exogenous amines, including toxins, precursors of toxins (like 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), or false transmitters, and of endogenous amines, such as neurotransmitters. In this study a highly polymorphic (GT)n repeat element was used to mark alleles at the MAOB locus. The MAOB allele status and levels of platelet MAO-B activity were determined for 41 control males. No correlation was noted between specific alleles and levels of MAO-B activity in this sample set. This suggests that the structural gene for MAOB is not usually the primary determinant of activity levels in platelets.

Original languageEnglish
Pages (from-to)2063-2066
Number of pages4
JournalJournal of Neurochemistry
Volume59
Issue number6
StatePublished - Dec 1992

Fingerprint

Monoamine Oxidase
Platelets
Blood Platelets
Alleles
Amines
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Nervous System Diseases
Neurotransmitter Agents
Psychiatry
Transmitters
Genes
Degradation

Keywords

  • GT-repeat element
  • Human
  • Monoamine oxidase A
  • Monoamine oxidase b
  • Platelets

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Girmen, A. S., Baenziger, J., Hotamisligil, G. S., Konradi, C., Shalish, C., Sullivan, J. L., & Breakefield, X. O. (1992). Relationship between platelet monoamine oxidase B activity and alleles at the MAOB locus. Journal of Neurochemistry, 59(6), 2063-2066.

Relationship between platelet monoamine oxidase B activity and alleles at the MAOB locus. / Girmen, A. Sule; Baenziger, John; Hotamisligil, Gokhan S.; Konradi, Christine; Shalish, Christo; Sullivan, Jack L.; Breakefield, Xandra O.

In: Journal of Neurochemistry, Vol. 59, No. 6, 12.1992, p. 2063-2066.

Research output: Contribution to journalArticle

Girmen, AS, Baenziger, J, Hotamisligil, GS, Konradi, C, Shalish, C, Sullivan, JL & Breakefield, XO 1992, 'Relationship between platelet monoamine oxidase B activity and alleles at the MAOB locus', Journal of Neurochemistry, vol. 59, no. 6, pp. 2063-2066.
Girmen AS, Baenziger J, Hotamisligil GS, Konradi C, Shalish C, Sullivan JL et al. Relationship between platelet monoamine oxidase B activity and alleles at the MAOB locus. Journal of Neurochemistry. 1992 Dec;59(6):2063-2066.
Girmen, A. Sule ; Baenziger, John ; Hotamisligil, Gokhan S. ; Konradi, Christine ; Shalish, Christo ; Sullivan, Jack L. ; Breakefield, Xandra O. / Relationship between platelet monoamine oxidase B activity and alleles at the MAOB locus. In: Journal of Neurochemistry. 1992 ; Vol. 59, No. 6. pp. 2063-2066.
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