Relationship Between Platelet Monoamine Oxidase B Activity and Alleles at the MAOB Locus

A. Sule Girmen, John Baenziger, Gokhan S. Hotamisligil, Christine Konradi, Christo Shalish, Jack L. Sullivan, Xandra O. Breakefield

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Genetic variations in monoamine oxidase (MAO)-B activity have been proposed to have a contributory role in several neurologic and psychiatric diseases. Variations in activity could affect rates of degradation of exogenous amines, including toxins, precursors of toxins (like 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), or false transmitters, and of endogenous amines, such as neurotransmitters. In this study a highly polymorphic (GT)n repeat element was used to mark alleles at the MAOB locus. The MAOB allele status and levels of platelet MAO-B activity were determined for 41 control males. No correlation was noted between specific alleles and levels of MAO-B activity in this sample set. This suggests that the structural gene for MAOB is not usually the primary determinant of activity levels in platelets.

Original languageEnglish (US)
Pages (from-to)2063-2066
Number of pages4
JournalJournal of Neurochemistry
Volume59
Issue number6
DOIs
StatePublished - Dec 1992

Keywords

  • GT-repeat element
  • Human
  • Monoamine oxidase A
  • Monoamine oxidase b
  • Platelets

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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    Girmen, A. S., Baenziger, J., Hotamisligil, G. S., Konradi, C., Shalish, C., Sullivan, J. L., & Breakefield, X. O. (1992). Relationship Between Platelet Monoamine Oxidase B Activity and Alleles at the MAOB Locus. Journal of Neurochemistry, 59(6), 2063-2066. https://doi.org/10.1111/j.1471-4159.1992.tb10095.x