Relationship between polycyclic aromatic hydrocarbon-DNA adducts, environmental tobacco smoke, and child development in the World Trade Center Cohort

Frederica P. Perera, Deliang Tang, Virginia Rauh, Yi Hsuan Tu, Wei Yann Tsai, Mark Becker, Janet L. Stein, Jeffrey King, Giuseppe Del Priore, Sally Ann Lederman

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Background: Polycydic aromatic hydrocarbons (PAHs), including benzo[a]pyrene (BaP), are air pollutants released by the World Trade Center (WTC) fires and urban combustion sources. BaP-DNA adducts provide a measure of PAH-specific genetic damage, which has been associated with increased risk of adverse birth outcomes and cancer. We previously reported that levels of BaP-DNA adducts in maternal and umbilical cord blood obtained at delivery were elevated among subjects who had resided within 1 mile of the WTC site during the month after 9/11; and that elevated blood adducts in combination with in utero exposures to environmental tobacco smoke (ETS) were significantly associated with decreased fetal growth. Objective: Our aim was to assess possible effects of prenatal exposure to WTC pollutants on child development. Methods: After 11 September 2001, we enrolled a cohort of nonsmoking pregnant women who delivered at three lower Manhattan hospitals. We have followed a subset of children through their third birthdays and measured cognitive and motor development using the Bayley-II Scales of Child Development (BSID-II). Results: In multivariate analyses, we found a significant interaction between cord blood adducts and in utero exposure to ETS on mental development index score at 3 years of age (p = 0.02, n = 98) whereas neither adducts nor ETS alone was a significant predictor of (BSID-II) cognitive development. Conclusion: Although limited by small numbers, these results suggest that exposure to elevated levels of PAHs in conjunction with prenatal ETS exposure may have contributed to a modest reduction in cognitive development among cohort children.

Original languageEnglish (US)
Pages (from-to)1497-1502
Number of pages6
JournalEnvironmental Health Perspectives
Volume115
Issue number10
DOIs
StatePublished - Oct 2007
Externally publishedYes

Fingerprint

World Trade Center
child development
Tobacco
Child Development
Aromatic Hydrocarbons
Smoke
PAH
DNA
aromatic hydrocarbon
Blood
Environmental Exposure
Fetal Blood
blood
Air Pollutants
Benzo(a)pyrene
Fetal Development
Pregnant Women
Fires
pyrene
Multivariate Analysis

Keywords

  • Child development
  • DNA adducts
  • ETS
  • IN utero
  • PAHs
  • World Trade Center

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

Cite this

Relationship between polycyclic aromatic hydrocarbon-DNA adducts, environmental tobacco smoke, and child development in the World Trade Center Cohort. / Perera, Frederica P.; Tang, Deliang; Rauh, Virginia; Tu, Yi Hsuan; Tsai, Wei Yann; Becker, Mark; Stein, Janet L.; King, Jeffrey; Del Priore, Giuseppe; Lederman, Sally Ann.

In: Environmental Health Perspectives, Vol. 115, No. 10, 10.2007, p. 1497-1502.

Research output: Contribution to journalArticle

Perera, FP, Tang, D, Rauh, V, Tu, YH, Tsai, WY, Becker, M, Stein, JL, King, J, Del Priore, G & Lederman, SA 2007, 'Relationship between polycyclic aromatic hydrocarbon-DNA adducts, environmental tobacco smoke, and child development in the World Trade Center Cohort', Environmental Health Perspectives, vol. 115, no. 10, pp. 1497-1502. https://doi.org/10.1289/ehp.10144
Perera, Frederica P. ; Tang, Deliang ; Rauh, Virginia ; Tu, Yi Hsuan ; Tsai, Wei Yann ; Becker, Mark ; Stein, Janet L. ; King, Jeffrey ; Del Priore, Giuseppe ; Lederman, Sally Ann. / Relationship between polycyclic aromatic hydrocarbon-DNA adducts, environmental tobacco smoke, and child development in the World Trade Center Cohort. In: Environmental Health Perspectives. 2007 ; Vol. 115, No. 10. pp. 1497-1502.
@article{dd0c9b418bb248eea3109a3e01bd5851,
title = "Relationship between polycyclic aromatic hydrocarbon-DNA adducts, environmental tobacco smoke, and child development in the World Trade Center Cohort",
abstract = "Background: Polycydic aromatic hydrocarbons (PAHs), including benzo[a]pyrene (BaP), are air pollutants released by the World Trade Center (WTC) fires and urban combustion sources. BaP-DNA adducts provide a measure of PAH-specific genetic damage, which has been associated with increased risk of adverse birth outcomes and cancer. We previously reported that levels of BaP-DNA adducts in maternal and umbilical cord blood obtained at delivery were elevated among subjects who had resided within 1 mile of the WTC site during the month after 9/11; and that elevated blood adducts in combination with in utero exposures to environmental tobacco smoke (ETS) were significantly associated with decreased fetal growth. Objective: Our aim was to assess possible effects of prenatal exposure to WTC pollutants on child development. Methods: After 11 September 2001, we enrolled a cohort of nonsmoking pregnant women who delivered at three lower Manhattan hospitals. We have followed a subset of children through their third birthdays and measured cognitive and motor development using the Bayley-II Scales of Child Development (BSID-II). Results: In multivariate analyses, we found a significant interaction between cord blood adducts and in utero exposure to ETS on mental development index score at 3 years of age (p = 0.02, n = 98) whereas neither adducts nor ETS alone was a significant predictor of (BSID-II) cognitive development. Conclusion: Although limited by small numbers, these results suggest that exposure to elevated levels of PAHs in conjunction with prenatal ETS exposure may have contributed to a modest reduction in cognitive development among cohort children.",
keywords = "Child development, DNA adducts, ETS, IN utero, PAHs, World Trade Center",
author = "Perera, {Frederica P.} and Deliang Tang and Virginia Rauh and Tu, {Yi Hsuan} and Tsai, {Wei Yann} and Mark Becker and Stein, {Janet L.} and Jeffrey King and {Del Priore}, Giuseppe and Lederman, {Sally Ann}",
year = "2007",
month = "10",
doi = "10.1289/ehp.10144",
language = "English (US)",
volume = "115",
pages = "1497--1502",
journal = "Environmental Health Perspectives",
issn = "0091-6765",
publisher = "Public Health Services, US Dept of Health and Human Services",
number = "10",

}

TY - JOUR

T1 - Relationship between polycyclic aromatic hydrocarbon-DNA adducts, environmental tobacco smoke, and child development in the World Trade Center Cohort

AU - Perera, Frederica P.

AU - Tang, Deliang

AU - Rauh, Virginia

AU - Tu, Yi Hsuan

AU - Tsai, Wei Yann

AU - Becker, Mark

AU - Stein, Janet L.

AU - King, Jeffrey

AU - Del Priore, Giuseppe

AU - Lederman, Sally Ann

PY - 2007/10

Y1 - 2007/10

N2 - Background: Polycydic aromatic hydrocarbons (PAHs), including benzo[a]pyrene (BaP), are air pollutants released by the World Trade Center (WTC) fires and urban combustion sources. BaP-DNA adducts provide a measure of PAH-specific genetic damage, which has been associated with increased risk of adverse birth outcomes and cancer. We previously reported that levels of BaP-DNA adducts in maternal and umbilical cord blood obtained at delivery were elevated among subjects who had resided within 1 mile of the WTC site during the month after 9/11; and that elevated blood adducts in combination with in utero exposures to environmental tobacco smoke (ETS) were significantly associated with decreased fetal growth. Objective: Our aim was to assess possible effects of prenatal exposure to WTC pollutants on child development. Methods: After 11 September 2001, we enrolled a cohort of nonsmoking pregnant women who delivered at three lower Manhattan hospitals. We have followed a subset of children through their third birthdays and measured cognitive and motor development using the Bayley-II Scales of Child Development (BSID-II). Results: In multivariate analyses, we found a significant interaction between cord blood adducts and in utero exposure to ETS on mental development index score at 3 years of age (p = 0.02, n = 98) whereas neither adducts nor ETS alone was a significant predictor of (BSID-II) cognitive development. Conclusion: Although limited by small numbers, these results suggest that exposure to elevated levels of PAHs in conjunction with prenatal ETS exposure may have contributed to a modest reduction in cognitive development among cohort children.

AB - Background: Polycydic aromatic hydrocarbons (PAHs), including benzo[a]pyrene (BaP), are air pollutants released by the World Trade Center (WTC) fires and urban combustion sources. BaP-DNA adducts provide a measure of PAH-specific genetic damage, which has been associated with increased risk of adverse birth outcomes and cancer. We previously reported that levels of BaP-DNA adducts in maternal and umbilical cord blood obtained at delivery were elevated among subjects who had resided within 1 mile of the WTC site during the month after 9/11; and that elevated blood adducts in combination with in utero exposures to environmental tobacco smoke (ETS) were significantly associated with decreased fetal growth. Objective: Our aim was to assess possible effects of prenatal exposure to WTC pollutants on child development. Methods: After 11 September 2001, we enrolled a cohort of nonsmoking pregnant women who delivered at three lower Manhattan hospitals. We have followed a subset of children through their third birthdays and measured cognitive and motor development using the Bayley-II Scales of Child Development (BSID-II). Results: In multivariate analyses, we found a significant interaction between cord blood adducts and in utero exposure to ETS on mental development index score at 3 years of age (p = 0.02, n = 98) whereas neither adducts nor ETS alone was a significant predictor of (BSID-II) cognitive development. Conclusion: Although limited by small numbers, these results suggest that exposure to elevated levels of PAHs in conjunction with prenatal ETS exposure may have contributed to a modest reduction in cognitive development among cohort children.

KW - Child development

KW - DNA adducts

KW - ETS

KW - IN utero

KW - PAHs

KW - World Trade Center

UR - http://www.scopus.com/inward/record.url?scp=35448929485&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35448929485&partnerID=8YFLogxK

U2 - 10.1289/ehp.10144

DO - 10.1289/ehp.10144

M3 - Article

VL - 115

SP - 1497

EP - 1502

JO - Environmental Health Perspectives

JF - Environmental Health Perspectives

SN - 0091-6765

IS - 10

ER -