Relationship between radiosurgery conformity indices and acoustic neuroma tumor volume

Michael V. Lawrence, Peter Rossi, Doug Powell, Kenneth E. Ekstrand, Allan F. Deguzman, Michael T. Munley, Thomas L. Ellis, Stephen B. Tatter, Volker W. Stieber, Kevin P. McMullen, Edward G. Shaw, J. Daniel Bourland

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Background: We reviewed the relationship between 4 conformation indices (CIs) and acoustic neuroma volumes to determine how CIs change with tumor volume (TV). Methods: Gamma Knife® (GK) stereotactic radiosurgery (SRS) plans for 96 acoustic neuroma patients were examined and the prescription isodose volume (PIV), T V, and TV receiving the prescription isodose (TV PIV) were recorded. The 4 CIs calculated were the following ratios: PIV/TV, TVPIV/TV, TVPIV/PIV, and TVPIV 2/(TV × PIV). CIs were stratified based upon TV as <2.0 cm3 (n = 49) or > 2.0 cm3 (n = 47). Results: For TVs <2.0 cm3, the mean PIV/TV, TVPIV/ TV, TV PIV/PIV, and TVPIV2/(TV × PIV) ratios were 1.984, 0.982, 0.588, and 0.577 respectively. For TVs > 2.0 cm 3, the mean PIV/TV, TVPIV/TV, TVPIV/PIV, and TVPIV2/(TV × PIV) ratios were 1.272, 0.971, 0.777, and 0.754 respectively. Conclusions: The PIV/TV, TVPIV/ PIV, and TVPIV2/(TV × PIV) ratios improved as TV increased whereas the TVPIV/TV ratio decreased. The greatest variance in the CIs was present at very small TVs. We conclude that CIs can be used to compare GK SRS plans for target volumes > 2.0 cm3.

Original languageEnglish (US)
Title of host publicationRadiosurgery
Pages95-99
Number of pages5
Volume7
DOIs
StatePublished - 2010
Externally publishedYes

Publication series

NameRadiosurgery
Volume7
ISSN (Print)10242651
ISSN (Electronic)16623940

Fingerprint

Acoustic Neuroma
Radiosurgery
Tumor Burden
Prescriptions

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Surgery
  • Medicine(all)

Cite this

Lawrence, M. V., Rossi, P., Powell, D., Ekstrand, K. E., Deguzman, A. F., Munley, M. T., ... Bourland, J. D. (2010). Relationship between radiosurgery conformity indices and acoustic neuroma tumor volume. In Radiosurgery (Vol. 7, pp. 95-99). (Radiosurgery; Vol. 7). https://doi.org/10.1159/000288722

Relationship between radiosurgery conformity indices and acoustic neuroma tumor volume. / Lawrence, Michael V.; Rossi, Peter; Powell, Doug; Ekstrand, Kenneth E.; Deguzman, Allan F.; Munley, Michael T.; Ellis, Thomas L.; Tatter, Stephen B.; Stieber, Volker W.; McMullen, Kevin P.; Shaw, Edward G.; Bourland, J. Daniel.

Radiosurgery. Vol. 7 2010. p. 95-99 (Radiosurgery; Vol. 7).

Research output: Chapter in Book/Report/Conference proceedingChapter

Lawrence, MV, Rossi, P, Powell, D, Ekstrand, KE, Deguzman, AF, Munley, MT, Ellis, TL, Tatter, SB, Stieber, VW, McMullen, KP, Shaw, EG & Bourland, JD 2010, Relationship between radiosurgery conformity indices and acoustic neuroma tumor volume. in Radiosurgery. vol. 7, Radiosurgery, vol. 7, pp. 95-99. https://doi.org/10.1159/000288722
Lawrence MV, Rossi P, Powell D, Ekstrand KE, Deguzman AF, Munley MT et al. Relationship between radiosurgery conformity indices and acoustic neuroma tumor volume. In Radiosurgery. Vol. 7. 2010. p. 95-99. (Radiosurgery). https://doi.org/10.1159/000288722
Lawrence, Michael V. ; Rossi, Peter ; Powell, Doug ; Ekstrand, Kenneth E. ; Deguzman, Allan F. ; Munley, Michael T. ; Ellis, Thomas L. ; Tatter, Stephen B. ; Stieber, Volker W. ; McMullen, Kevin P. ; Shaw, Edward G. ; Bourland, J. Daniel. / Relationship between radiosurgery conformity indices and acoustic neuroma tumor volume. Radiosurgery. Vol. 7 2010. pp. 95-99 (Radiosurgery).
@inbook{56210c37b12041209467d9d2b1c879e2,
title = "Relationship between radiosurgery conformity indices and acoustic neuroma tumor volume",
abstract = "Background: We reviewed the relationship between 4 conformation indices (CIs) and acoustic neuroma volumes to determine how CIs change with tumor volume (TV). Methods: Gamma Knife{\circledR} (GK) stereotactic radiosurgery (SRS) plans for 96 acoustic neuroma patients were examined and the prescription isodose volume (PIV), T V, and TV receiving the prescription isodose (TV PIV) were recorded. The 4 CIs calculated were the following ratios: PIV/TV, TVPIV/TV, TVPIV/PIV, and TVPIV 2/(TV × PIV). CIs were stratified based upon TV as <2.0 cm3 (n = 49) or > 2.0 cm3 (n = 47). Results: For TVs <2.0 cm3, the mean PIV/TV, TVPIV/ TV, TV PIV/PIV, and TVPIV2/(TV × PIV) ratios were 1.984, 0.982, 0.588, and 0.577 respectively. For TVs > 2.0 cm 3, the mean PIV/TV, TVPIV/TV, TVPIV/PIV, and TVPIV2/(TV × PIV) ratios were 1.272, 0.971, 0.777, and 0.754 respectively. Conclusions: The PIV/TV, TVPIV/ PIV, and TVPIV2/(TV × PIV) ratios improved as TV increased whereas the TVPIV/TV ratio decreased. The greatest variance in the CIs was present at very small TVs. We conclude that CIs can be used to compare GK SRS plans for target volumes > 2.0 cm3.",
author = "Lawrence, {Michael V.} and Peter Rossi and Doug Powell and Ekstrand, {Kenneth E.} and Deguzman, {Allan F.} and Munley, {Michael T.} and Ellis, {Thomas L.} and Tatter, {Stephen B.} and Stieber, {Volker W.} and McMullen, {Kevin P.} and Shaw, {Edward G.} and Bourland, {J. Daniel}",
year = "2010",
doi = "10.1159/000288722",
language = "English (US)",
isbn = "9783805593649",
volume = "7",
series = "Radiosurgery",
pages = "95--99",
booktitle = "Radiosurgery",

}

TY - CHAP

T1 - Relationship between radiosurgery conformity indices and acoustic neuroma tumor volume

AU - Lawrence, Michael V.

AU - Rossi, Peter

AU - Powell, Doug

AU - Ekstrand, Kenneth E.

AU - Deguzman, Allan F.

AU - Munley, Michael T.

AU - Ellis, Thomas L.

AU - Tatter, Stephen B.

AU - Stieber, Volker W.

AU - McMullen, Kevin P.

AU - Shaw, Edward G.

AU - Bourland, J. Daniel

PY - 2010

Y1 - 2010

N2 - Background: We reviewed the relationship between 4 conformation indices (CIs) and acoustic neuroma volumes to determine how CIs change with tumor volume (TV). Methods: Gamma Knife® (GK) stereotactic radiosurgery (SRS) plans for 96 acoustic neuroma patients were examined and the prescription isodose volume (PIV), T V, and TV receiving the prescription isodose (TV PIV) were recorded. The 4 CIs calculated were the following ratios: PIV/TV, TVPIV/TV, TVPIV/PIV, and TVPIV 2/(TV × PIV). CIs were stratified based upon TV as <2.0 cm3 (n = 49) or > 2.0 cm3 (n = 47). Results: For TVs <2.0 cm3, the mean PIV/TV, TVPIV/ TV, TV PIV/PIV, and TVPIV2/(TV × PIV) ratios were 1.984, 0.982, 0.588, and 0.577 respectively. For TVs > 2.0 cm 3, the mean PIV/TV, TVPIV/TV, TVPIV/PIV, and TVPIV2/(TV × PIV) ratios were 1.272, 0.971, 0.777, and 0.754 respectively. Conclusions: The PIV/TV, TVPIV/ PIV, and TVPIV2/(TV × PIV) ratios improved as TV increased whereas the TVPIV/TV ratio decreased. The greatest variance in the CIs was present at very small TVs. We conclude that CIs can be used to compare GK SRS plans for target volumes > 2.0 cm3.

AB - Background: We reviewed the relationship between 4 conformation indices (CIs) and acoustic neuroma volumes to determine how CIs change with tumor volume (TV). Methods: Gamma Knife® (GK) stereotactic radiosurgery (SRS) plans for 96 acoustic neuroma patients were examined and the prescription isodose volume (PIV), T V, and TV receiving the prescription isodose (TV PIV) were recorded. The 4 CIs calculated were the following ratios: PIV/TV, TVPIV/TV, TVPIV/PIV, and TVPIV 2/(TV × PIV). CIs were stratified based upon TV as <2.0 cm3 (n = 49) or > 2.0 cm3 (n = 47). Results: For TVs <2.0 cm3, the mean PIV/TV, TVPIV/ TV, TV PIV/PIV, and TVPIV2/(TV × PIV) ratios were 1.984, 0.982, 0.588, and 0.577 respectively. For TVs > 2.0 cm 3, the mean PIV/TV, TVPIV/TV, TVPIV/PIV, and TVPIV2/(TV × PIV) ratios were 1.272, 0.971, 0.777, and 0.754 respectively. Conclusions: The PIV/TV, TVPIV/ PIV, and TVPIV2/(TV × PIV) ratios improved as TV increased whereas the TVPIV/TV ratio decreased. The greatest variance in the CIs was present at very small TVs. We conclude that CIs can be used to compare GK SRS plans for target volumes > 2.0 cm3.

UR - http://www.scopus.com/inward/record.url?scp=77949399808&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949399808&partnerID=8YFLogxK

U2 - 10.1159/000288722

DO - 10.1159/000288722

M3 - Chapter

SN - 9783805593649

VL - 7

T3 - Radiosurgery

SP - 95

EP - 99

BT - Radiosurgery

ER -