Relationship between steady-state plasma nizatidine concentrations and inhibition of basal and stimulated gastric acid secretion

Dennis W. Schneck, John T. Callaghan, Richard F. Bergstrom, Boyd D. Obermeyer, Walter W. Offen

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Steady-state plasma nizatidine concentrations were related in a linear fashion to nizatidine infusion rate. Infusion rates of 2.5, 10, and 20 mg/hr resulted in mean plasma nizatidine concentrations of 69, 247, and 575 ng/ml. Basal acid secretion was inhibited by 50% and 90% at mean plasma nizatidine concentrations of 60 and 430 ng/ml. Protein-stimulated acid secretion was inhibited by 50% and 90% at mean plasma nizatidine concentrations of 75 and 490 ng/ml. The mean pH of basal gastric secretions was 1.6 during placebo infusion and 4.6 when the mean plasma nizatidine concentration was 575 ng/ml.

Original languageEnglish (US)
Pages (from-to)499-503
Number of pages5
JournalClinical Pharmacology and Therapeutics
Volume47
Issue number4
DOIs
StatePublished - Apr 1990

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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