Relationship between steady-state plasma nizatidine concentrations and inhibition of basal and stimulated gastric acid secretion

Dennis W. Schneck, John Callaghan, Richard F. Bergstrom, Boyd D. Obermeyer, Walter W. Offen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Steady-state plasma nizatidine concentrations were related in a linear fashion to nizatidine infusion rate. Infusion rates of 2.5, 10, and 20 mg/hr resulted in mean plasma nizatidine concentrations of 69, 247, and 575 ng/ml. Basal acid secretion was inhibited by 50% and 90% at mean plasma nizatidine concentrations of 60 and 430 ng/ml. Protein-stimulated acid secretion was inhibited by 50% and 90% at mean plasma nizatidine concentrations of 75 and 490 ng/ml. The mean pH of basal gastric secretions was 1.6 during placebo infusion and 4.6 when the mean plasma nizatidine concentration was 575 ng/ml.

Original languageEnglish (US)
Pages (from-to)499-503
Number of pages5
JournalClinical Pharmacology and Therapeutics
Volume47
Issue number4
StatePublished - Apr 1990

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Nizatidine
Gastric Acid
Acids
Stomach
Placebos

ASJC Scopus subject areas

  • Pharmacology

Cite this

Relationship between steady-state plasma nizatidine concentrations and inhibition of basal and stimulated gastric acid secretion. / Schneck, Dennis W.; Callaghan, John; Bergstrom, Richard F.; Obermeyer, Boyd D.; Offen, Walter W.

In: Clinical Pharmacology and Therapeutics, Vol. 47, No. 4, 04.1990, p. 499-503.

Research output: Contribution to journalArticle

Schneck, Dennis W. ; Callaghan, John ; Bergstrom, Richard F. ; Obermeyer, Boyd D. ; Offen, Walter W. / Relationship between steady-state plasma nizatidine concentrations and inhibition of basal and stimulated gastric acid secretion. In: Clinical Pharmacology and Therapeutics. 1990 ; Vol. 47, No. 4. pp. 499-503.
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