Relationship between steroid receptors and response to endocrine therapy and cytotoxic chemotherapy in metastatic breast cancer

P. C M Young, C. E. Ehrlich, Lawrence Einhorn

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The relationship between steroid receptor content and response of metastatic breast cancers to endocrine therapy and cytotoxic chemotherapy has been examined. In 54 advanced breast cancers treated with hormonal therapy, 20 of 29 (69%) ER+, PR+ and 3 of 14 (21%) ER+, PR-tumors responded. Of the nine tumors that lacked both ER and PR, 2 (22%) were hormonally responsive. Based on either the ER or PR content alone, 68% of the PR+ and 54% of the ER+ tumors responded to endocrine therapy. Thus, the addition of PR assay could improve the accuracy of ER assay in selecting a hormonally responsive breast cancer. In 29 advanced breast cancers treated with cytotoxic drugs, the presence of ER and/or PR in the tumors seemed to favor an objective response to cytotoxic chemotherapy. The response rate was about 67% regardless of whether the cancers were ER+ or PR+.

Original languageEnglish
Pages (from-to)2961-2963
Number of pages3
JournalCancer
Volume46
Issue number12 SUPPL.
StatePublished - 1980

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Steroid Receptors
Breast Neoplasms
Drug Therapy
Neoplasms
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Relationship between steroid receptors and response to endocrine therapy and cytotoxic chemotherapy in metastatic breast cancer. / Young, P. C M; Ehrlich, C. E.; Einhorn, Lawrence.

In: Cancer, Vol. 46, No. 12 SUPPL., 1980, p. 2961-2963.

Research output: Contribution to journalArticle

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abstract = "The relationship between steroid receptor content and response of metastatic breast cancers to endocrine therapy and cytotoxic chemotherapy has been examined. In 54 advanced breast cancers treated with hormonal therapy, 20 of 29 (69{\%}) ER+, PR+ and 3 of 14 (21{\%}) ER+, PR-tumors responded. Of the nine tumors that lacked both ER and PR, 2 (22{\%}) were hormonally responsive. Based on either the ER or PR content alone, 68{\%} of the PR+ and 54{\%} of the ER+ tumors responded to endocrine therapy. Thus, the addition of PR assay could improve the accuracy of ER assay in selecting a hormonally responsive breast cancer. In 29 advanced breast cancers treated with cytotoxic drugs, the presence of ER and/or PR in the tumors seemed to favor an objective response to cytotoxic chemotherapy. The response rate was about 67{\%} regardless of whether the cancers were ER+ or PR+.",
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