Relationship between structure and function of liver mitochondria from hibernating and active ground squirrels, Citellus undulatus

Nikolai Broustovetski, M. V. Egorova, E. N. Iljasova, L. E. Bakeeva

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

1. 1. Electron microscopy of liver tissue preparations, obtained from hibernating ground squirrels, reveals mitochondria in a condensed state. 2. 2. When kept on ice, mitochondria isolated from the livers of hibernating and active ground squirrels are in a shrunken state. 3. 3. Incubation of mitochondria isolated from the livers of active ground squirrels in the presence of succinate, at 27°C, results in mitochondrial swelling, while mitochondria from hibernating ground squirrels under the same conditions remain relatively shrunken. 4. 4. The swollen mitochondria from active ground squirrels show high oxidative activity, while the shrunken mitochondria from hibernating animals show low oxidative activity. 5. 5. Swelling of mitochondria from hibernating ground squirrels in a hypo-osmolar medium is accompanied by a significant increase in oxidative activity. 6. 6. It is inferred that the shrinkage of hibernating ground squirrel mitochondria is one of the main causes of the inhibition of oxidative activity and other mitochondrial functions during hibernation.

Original languageEnglish (US)
Pages (from-to)125-130
Number of pages6
JournalComparative Biochemistry and Physiology -- Part B: Biochemistry and
Volume106
Issue number1
DOIs
StatePublished - 1993
Externally publishedYes

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Sciuridae
Mitochondria
Liver Mitochondrion
Liver
Swelling
Mitochondrial Swelling
Hibernation
Ice
Succinic Acid
Electron Microscopy
Electron microscopy
Animals
Tissue

ASJC Scopus subject areas

  • Biochemistry
  • Physiology

Cite this

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title = "Relationship between structure and function of liver mitochondria from hibernating and active ground squirrels, Citellus undulatus",
abstract = "1. 1. Electron microscopy of liver tissue preparations, obtained from hibernating ground squirrels, reveals mitochondria in a condensed state. 2. 2. When kept on ice, mitochondria isolated from the livers of hibernating and active ground squirrels are in a shrunken state. 3. 3. Incubation of mitochondria isolated from the livers of active ground squirrels in the presence of succinate, at 27°C, results in mitochondrial swelling, while mitochondria from hibernating ground squirrels under the same conditions remain relatively shrunken. 4. 4. The swollen mitochondria from active ground squirrels show high oxidative activity, while the shrunken mitochondria from hibernating animals show low oxidative activity. 5. 5. Swelling of mitochondria from hibernating ground squirrels in a hypo-osmolar medium is accompanied by a significant increase in oxidative activity. 6. 6. It is inferred that the shrinkage of hibernating ground squirrel mitochondria is one of the main causes of the inhibition of oxidative activity and other mitochondrial functions during hibernation.",
author = "Nikolai Broustovetski and Egorova, {M. V.} and Iljasova, {E. N.} and Bakeeva, {L. E.}",
year = "1993",
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pages = "125--130",
journal = "Comparative Biochemistry and Physiology -- Part B: Biochemistry and",
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TY - JOUR

T1 - Relationship between structure and function of liver mitochondria from hibernating and active ground squirrels, Citellus undulatus

AU - Broustovetski, Nikolai

AU - Egorova, M. V.

AU - Iljasova, E. N.

AU - Bakeeva, L. E.

PY - 1993

Y1 - 1993

N2 - 1. 1. Electron microscopy of liver tissue preparations, obtained from hibernating ground squirrels, reveals mitochondria in a condensed state. 2. 2. When kept on ice, mitochondria isolated from the livers of hibernating and active ground squirrels are in a shrunken state. 3. 3. Incubation of mitochondria isolated from the livers of active ground squirrels in the presence of succinate, at 27°C, results in mitochondrial swelling, while mitochondria from hibernating ground squirrels under the same conditions remain relatively shrunken. 4. 4. The swollen mitochondria from active ground squirrels show high oxidative activity, while the shrunken mitochondria from hibernating animals show low oxidative activity. 5. 5. Swelling of mitochondria from hibernating ground squirrels in a hypo-osmolar medium is accompanied by a significant increase in oxidative activity. 6. 6. It is inferred that the shrinkage of hibernating ground squirrel mitochondria is one of the main causes of the inhibition of oxidative activity and other mitochondrial functions during hibernation.

AB - 1. 1. Electron microscopy of liver tissue preparations, obtained from hibernating ground squirrels, reveals mitochondria in a condensed state. 2. 2. When kept on ice, mitochondria isolated from the livers of hibernating and active ground squirrels are in a shrunken state. 3. 3. Incubation of mitochondria isolated from the livers of active ground squirrels in the presence of succinate, at 27°C, results in mitochondrial swelling, while mitochondria from hibernating ground squirrels under the same conditions remain relatively shrunken. 4. 4. The swollen mitochondria from active ground squirrels show high oxidative activity, while the shrunken mitochondria from hibernating animals show low oxidative activity. 5. 5. Swelling of mitochondria from hibernating ground squirrels in a hypo-osmolar medium is accompanied by a significant increase in oxidative activity. 6. 6. It is inferred that the shrinkage of hibernating ground squirrel mitochondria is one of the main causes of the inhibition of oxidative activity and other mitochondrial functions during hibernation.

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U2 - 10.1016/0305-0491(93)90017-Y

DO - 10.1016/0305-0491(93)90017-Y

M3 - Article

VL - 106

SP - 125

EP - 130

JO - Comparative Biochemistry and Physiology -- Part B: Biochemistry and

JF - Comparative Biochemistry and Physiology -- Part B: Biochemistry and

SN - 0305-0491

IS - 1

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