Relationship of auditory electrophysiological responses to magnetic resonance spectroscopy metabolites in Early Phase Psychosis

Lisa A. Bartolomeo, Andrew M. Wright, Ruoyun E. Ma, Tom A. Hummer, Michael M. Francis, Andrew C. Visco, Nicole F. Mehdiyoun, Amanda R. Bolbecker, William P. Hetrick, Ulrike Dydak, John Barnard, Brian O'Donnell, Alan Breier

Research output: Contribution to journalArticle

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Abstract

Both auditory evoked responses and metabolites measured by magnetic resonance spectroscopy (MRS) are altered in schizophrenia and other psychotic disorders, but the relationship between electrophysiological and metabolic changes are not well characterized. We examined the relation of MRS metabolites to cognitive and electrophysiological measures in individuals during the early phase of psychosis (EPP) and in healthy control subjects. The mismatch negativity (MMN) of the auditory event-related potential to duration deviant tones and the auditory steady response (ASSR) to 40 Hz stimulation were assessed. MRS was used to quantify glutamate+glutamine (Glx), N-Acetylasparate (NAA), creatine (Cre), myo-inositol (Ins) and choline (Cho) at a voxel placed medially in the frontal cortex. MMN amplitude and ASSR power did not differ between groups. The MRS metabolites Glx, Cre and Cho were elevated in the psychosis group. Partial least squares analysis in the patient group indicated that elevated levels of MRS metabolites were associated with reduced MMN amplitude and increased 40 Hz ASSR power. There were no correlations between the neurobiological measures and clinical measures. These data suggest that elevated neurometabolites early in psychosis are accompanied by altered auditory neurotransmission, possibly indicative of a neuroinflammatory or excitotoxic disturbance which disrupts a wide range of metabolic processes in the cortex.

Original languageEnglish (US)
JournalInternational Journal of Psychophysiology
DOIs
StatePublished - Jan 1 2019

Fingerprint

Psychotic Disorders
Magnetic Resonance Spectroscopy
Creatine
Choline
Auditory Evoked Potentials
Frontal Lobe
Inositol
Least-Squares Analysis
Glutamine
Evoked Potentials
Synaptic Transmission
Glutamic Acid
Schizophrenia
Healthy Volunteers
Power (Psychology)

Keywords

  • Auditory steady state response
  • Event-related potentials
  • Magnetic resonance spectroscopy
  • Mismatch negativity
  • Psychosis
  • Schizophrenia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology
  • Physiology (medical)

Cite this

Relationship of auditory electrophysiological responses to magnetic resonance spectroscopy metabolites in Early Phase Psychosis. / Bartolomeo, Lisa A.; Wright, Andrew M.; Ma, Ruoyun E.; Hummer, Tom A.; Francis, Michael M.; Visco, Andrew C.; Mehdiyoun, Nicole F.; Bolbecker, Amanda R.; Hetrick, William P.; Dydak, Ulrike; Barnard, John; O'Donnell, Brian; Breier, Alan.

In: International Journal of Psychophysiology, 01.01.2019.

Research output: Contribution to journalArticle

Bartolomeo, Lisa A. ; Wright, Andrew M. ; Ma, Ruoyun E. ; Hummer, Tom A. ; Francis, Michael M. ; Visco, Andrew C. ; Mehdiyoun, Nicole F. ; Bolbecker, Amanda R. ; Hetrick, William P. ; Dydak, Ulrike ; Barnard, John ; O'Donnell, Brian ; Breier, Alan. / Relationship of auditory electrophysiological responses to magnetic resonance spectroscopy metabolites in Early Phase Psychosis. In: International Journal of Psychophysiology. 2019.
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