Relationship of body composition, metabolic status, antiretroviral use, and hiv disease factors to endothelial dysfunction in hiv-infected subjects

Michael P. Dubé, Changyu Shen, Kieren Mather, Jeff Waltz, Martha Greenwald, Samir Gupta

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Vascular endothelial dysfunction may contribute to the increase in cardiovascular events during HIV-1 infection and its treatment. Antiretroviral therapy (ART), metabolic factors, lipodystrophy, and HIV infection itself may be involved. Ninety-six HIV-infected subjects were evaluated for endothelial function by measurement of brachial artery flow-mediated dilation (FMD) by ultrasound, single-slice CT of the abdomen and mid-thigh, whole-body dual x-ray absorptiomety (DXA) scans, and metabolic evaluations in a cross-sectional study. The median age was 40 years; 28% were female, 38% black, 3% Hispanic, and 59% white. Forty-nine (51%) were receiving ART, which included a PI in 28 (57%) and was non-PI based in 21 (43%). FMD (±SD) in subjects not on ART was 5.5 ± 4.3%, PI-ART 5.3 ± 3.6%, and non-PI-ART 5.5 ± 4.1% (p=0.9). Age, race, CD4 cell count, and HIV RNA did not correlate significantly with FMD. Among ART-treated subjects in the lowest tertile of thigh subcutaneous fat area (range 3-31 cm2), FMD was 4.4 ± 3.5% and in the highest tertile (range 67-237 cm2) FMD was 6.8 ± 3.6% (p=0.07, t-test). However, in multivariate analyses, no body composition measure showed a significant association with FMD for either the group as a whole or in ART-treated subjects. ART use, PI use, CD4 cell count, and HIV RNA levels were not associated with endothelial dysfunction by brachial FMD. A definitive association with measures of adiposity was not detected in multivariate analysis, suggesting that lipoatrophy may not be an important contributor to endothelial dysfunction in HIV-infected individuals on ART.

Original languageEnglish
Pages (from-to)847-854
Number of pages8
JournalAIDS Research and Human Retroviruses
Volume26
Issue number8
DOIs
StatePublished - Aug 1 2010

Fingerprint

Body Composition
Dilatation
HIV
Therapeutics
CD4 Lymphocyte Count
Thigh
HIV Infections
Multivariate Analysis
RNA
Body Weights and Measures
Lipodystrophy
Brachial Artery
Subcutaneous Fat
Adiposity
Hispanic Americans
Abdomen
Blood Vessels
HIV-1
Arm
Cross-Sectional Studies

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases
  • Medicine(all)

Cite this

Relationship of body composition, metabolic status, antiretroviral use, and hiv disease factors to endothelial dysfunction in hiv-infected subjects. / Dubé, Michael P.; Shen, Changyu; Mather, Kieren; Waltz, Jeff; Greenwald, Martha; Gupta, Samir.

In: AIDS Research and Human Retroviruses, Vol. 26, No. 8, 01.08.2010, p. 847-854.

Research output: Contribution to journalArticle

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