Relationship of obesity to bile lithogenicity in man

J. A. Madura, R. C. Loomis, R. A. Harris, J. Grosfeld, R. K. Tompkins

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Gallbladder bile was aspirated and analyzed for content of bile salts, cholesterol, and phospholipids in 97 patients undergoing jejunoileal bypass. Lithogenic indices (LI) (mole % cholesterol in sample/mole % cholesterol at saturation) were correlated with age, sex, lipid levels and hepatic fatty metamorphosis. The overall incidence of gallstones in group was 43% (N = 121). Cholelithogenesis was unrelated to age, serum lipid concentrations, LI, or hepatic morphology. A significant relationship was noted between cholelithogenesis and female sex ( p < .03). The incidence of gallstones was greater in patients weighing more than 270% of ideal body weight and the LI greater in those weighing more than 230%. The mean IL of bile was greater than 1.0 (supersaturated) in all patients except nongallstone forming diabetics. The lithogenic index in diabetics without gallstones was 0.88 ± 0.11, while in nondiabetics without gallstones, the LI was 1.49 ± 0.10 ( p < 0.001). These observations indicate that grossly obese patients have an increased incidence of cholelithiasis, probably related to supersaturation of bile with cholesterol. In addition, female patients are especially at risk, while other parameters had little or no detectable influence on cholelithogenesis in this group of patients.

Original languageEnglish (US)
Pages (from-to)106-111
Number of pages6
JournalUnknown Journal
Volume189
Issue number1
DOIs
StatePublished - Jan 1 1979

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Bile
Obesity
Gallstones
Cholesterol
Incidence
Jejunoileal Bypass
Lipids
Ideal Body Weight
Cholelithiasis
Liver
Gallbladder
Bile Acids and Salts
Phospholipids
Serum

ASJC Scopus subject areas

  • Surgery

Cite this

Madura, J. A., Loomis, R. C., Harris, R. A., Grosfeld, J., & Tompkins, R. K. (1979). Relationship of obesity to bile lithogenicity in man. Unknown Journal, 189(1), 106-111. https://doi.org/10.1097/00000658-197901000-00020

Relationship of obesity to bile lithogenicity in man. / Madura, J. A.; Loomis, R. C.; Harris, R. A.; Grosfeld, J.; Tompkins, R. K.

In: Unknown Journal, Vol. 189, No. 1, 01.01.1979, p. 106-111.

Research output: Contribution to journalArticle

Madura, JA, Loomis, RC, Harris, RA, Grosfeld, J & Tompkins, RK 1979, 'Relationship of obesity to bile lithogenicity in man', Unknown Journal, vol. 189, no. 1, pp. 106-111. https://doi.org/10.1097/00000658-197901000-00020
Madura, J. A. ; Loomis, R. C. ; Harris, R. A. ; Grosfeld, J. ; Tompkins, R. K. / Relationship of obesity to bile lithogenicity in man. In: Unknown Journal. 1979 ; Vol. 189, No. 1. pp. 106-111.
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