Relationship of p21(WAF1) expression with disease-free survival and biochemical recurrence in prostate adenocarcinomas (PCa)

Fazlul H. Sarkar, Yiwei Li, Wael A. Sakr, David Grignon, Shahi S. Madan, David P. Wood, Volkan Adsay

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

BACKGROUND. The p21(WAF1) gene is considered to be one of the major regulators of the cell cycle. Its level of expression has been shown to correlate with pathologic stage and Gleason score in prostatic cancer. However, its relationship to clinical outcome is not yet well characterized. METHODS. Immunohistochemical staining for p21(WAF1) protein expression was performed in 62 consecutive radical prostatectomy specimens from our institution. The results were correlated with the disease-free survival and biochemical recurrence of the patients. RESULTS. Thirty-four of the 62 patients were Caucasian and 28 were African American. There was a significant correlation between p21(WAF1) expression and biochemical recurrence after radical prostatectomy (P <0.0095). However, while p21(WAF1) staining in prostate cancer was a prognostic indicator of disease-free survival in Caucasians (P <0.0001), it appeared not to be a factor in African-American men (P = 0.908). CONCLUSIONS. This study suggests that p21(WAF1) may have a role in the pathogenesis and progression of prostate carcinoma, and may serve as a predictor of biochemical recurrence of this tumor. The differences in the values of p21(WAF1) as a prognostic marker of disease-free survival in Caucasians vs. African Americans suggest that progression of prostate cancer may have different mechanisms in different ethnic groups.

Original languageEnglish (US)
Pages (from-to)256-260
Number of pages5
JournalProstate
Volume40
Issue number4
DOIs
StatePublished - 1999
Externally publishedYes

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African Americans
Disease-Free Survival
Prostate
Prostatic Neoplasms
Adenocarcinoma
Prostatectomy
Recurrence
Staining and Labeling
Neoplasm Grading
Ethnic Groups
Cell Cycle
Carcinoma
Genes
Neoplasms
Proteins

Keywords

  • Disease-free survival
  • P21(WAF1)
  • Prostatic carcinoma

ASJC Scopus subject areas

  • Urology

Cite this

Relationship of p21(WAF1) expression with disease-free survival and biochemical recurrence in prostate adenocarcinomas (PCa). / Sarkar, Fazlul H.; Li, Yiwei; Sakr, Wael A.; Grignon, David; Madan, Shahi S.; Wood, David P.; Adsay, Volkan.

In: Prostate, Vol. 40, No. 4, 1999, p. 256-260.

Research output: Contribution to journalArticle

Sarkar, Fazlul H. ; Li, Yiwei ; Sakr, Wael A. ; Grignon, David ; Madan, Shahi S. ; Wood, David P. ; Adsay, Volkan. / Relationship of p21(WAF1) expression with disease-free survival and biochemical recurrence in prostate adenocarcinomas (PCa). In: Prostate. 1999 ; Vol. 40, No. 4. pp. 256-260.
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T1 - Relationship of p21(WAF1) expression with disease-free survival and biochemical recurrence in prostate adenocarcinomas (PCa)

AU - Sarkar, Fazlul H.

AU - Li, Yiwei

AU - Sakr, Wael A.

AU - Grignon, David

AU - Madan, Shahi S.

AU - Wood, David P.

AU - Adsay, Volkan

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N2 - BACKGROUND. The p21(WAF1) gene is considered to be one of the major regulators of the cell cycle. Its level of expression has been shown to correlate with pathologic stage and Gleason score in prostatic cancer. However, its relationship to clinical outcome is not yet well characterized. METHODS. Immunohistochemical staining for p21(WAF1) protein expression was performed in 62 consecutive radical prostatectomy specimens from our institution. The results were correlated with the disease-free survival and biochemical recurrence of the patients. RESULTS. Thirty-four of the 62 patients were Caucasian and 28 were African American. There was a significant correlation between p21(WAF1) expression and biochemical recurrence after radical prostatectomy (P <0.0095). However, while p21(WAF1) staining in prostate cancer was a prognostic indicator of disease-free survival in Caucasians (P <0.0001), it appeared not to be a factor in African-American men (P = 0.908). CONCLUSIONS. This study suggests that p21(WAF1) may have a role in the pathogenesis and progression of prostate carcinoma, and may serve as a predictor of biochemical recurrence of this tumor. The differences in the values of p21(WAF1) as a prognostic marker of disease-free survival in Caucasians vs. African Americans suggest that progression of prostate cancer may have different mechanisms in different ethnic groups.

AB - BACKGROUND. The p21(WAF1) gene is considered to be one of the major regulators of the cell cycle. Its level of expression has been shown to correlate with pathologic stage and Gleason score in prostatic cancer. However, its relationship to clinical outcome is not yet well characterized. METHODS. Immunohistochemical staining for p21(WAF1) protein expression was performed in 62 consecutive radical prostatectomy specimens from our institution. The results were correlated with the disease-free survival and biochemical recurrence of the patients. RESULTS. Thirty-four of the 62 patients were Caucasian and 28 were African American. There was a significant correlation between p21(WAF1) expression and biochemical recurrence after radical prostatectomy (P <0.0095). However, while p21(WAF1) staining in prostate cancer was a prognostic indicator of disease-free survival in Caucasians (P <0.0001), it appeared not to be a factor in African-American men (P = 0.908). CONCLUSIONS. This study suggests that p21(WAF1) may have a role in the pathogenesis and progression of prostate carcinoma, and may serve as a predictor of biochemical recurrence of this tumor. The differences in the values of p21(WAF1) as a prognostic marker of disease-free survival in Caucasians vs. African Americans suggest that progression of prostate cancer may have different mechanisms in different ethnic groups.

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KW - P21(WAF1)

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