Relationship of prediagnostic body mass index with survival after colorectal cancer: Stage-specific associations

Jonathan M. Kocarnik, Andrew T. Chan, Martha L. Slattery, John D. Potter, Jeffrey Meyerhardt, Amanda Phipps, Hongmei Nan, Tabitha Harrison, Thomas E. Rohan, Lihong Qi, Lifang Hou, Bette Caan, Candyce H. Kroenke, Howard Strickler, Richard B. Hayes, Robert E. Schoen, Dawn Q. Chong, Emily White, Sonja I. Berndt, Ulrike PetersPolly A. Newcomb

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Higher body mass index (BMI) is a well-established risk factor for colorectal cancer (CRC), but is inconsistently associated with CRC survival. In 6 prospective studies participating in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), 2,249 non-Hispanic white CRC cases were followed for a median 4.5 years after diagnosis, during which 777 died, 554 from CRC-related causes. Associations between prediagnosis BMI and survival (overall and CRC-specific) were evaluated using Cox regression models adjusted for age at diagnosis, sex, study and smoking status (current/former/never). The association between BMI category and CRC survival varied by cancer stage at diagnosis (I-IV) for both all-cause (p-interaction = 0.03) and CRC-specific mortality (p-interaction = 0.04). Compared to normal BMI (18.5-24.9 kg/m2), overweight (BMI 25.0-29.9) was associated with increased mortality among those with Stage I disease, and decreased mortality among those with Stages II-IV disease. Similarly, obesity (BMI ≥30) was associated with increased mortality among those with Stages I-II disease, and decreased mortality among those with Stages III-IV disease. These results suggest the relationship between BMI and survival after CRC diagnosis differs by stage at diagnosis, and may emphasize the importance of adequate metabolic reserves for colorectal cancer survival in patients with late-stage disease.

Original languageEnglish (US)
Pages (from-to)1065-1072
Number of pages8
JournalInternational Journal of Cancer
Volume139
Issue number5
DOIs
StatePublished - Sep 1 2016

Fingerprint

Colorectal Neoplasms
Body Mass Index
Survival
Mortality
Molecular Epidemiology
Proportional Hazards Models
Obesity
Smoking
Prospective Studies

Keywords

  • body mass index (BMI)
  • cancer stage
  • colorectal cancer (CRC)
  • mortality
  • survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Kocarnik, J. M., Chan, A. T., Slattery, M. L., Potter, J. D., Meyerhardt, J., Phipps, A., ... Newcomb, P. A. (2016). Relationship of prediagnostic body mass index with survival after colorectal cancer: Stage-specific associations. International Journal of Cancer, 139(5), 1065-1072. https://doi.org/10.1002/ijc.30163

Relationship of prediagnostic body mass index with survival after colorectal cancer : Stage-specific associations. / Kocarnik, Jonathan M.; Chan, Andrew T.; Slattery, Martha L.; Potter, John D.; Meyerhardt, Jeffrey; Phipps, Amanda; Nan, Hongmei; Harrison, Tabitha; Rohan, Thomas E.; Qi, Lihong; Hou, Lifang; Caan, Bette; Kroenke, Candyce H.; Strickler, Howard; Hayes, Richard B.; Schoen, Robert E.; Chong, Dawn Q.; White, Emily; Berndt, Sonja I.; Peters, Ulrike; Newcomb, Polly A.

In: International Journal of Cancer, Vol. 139, No. 5, 01.09.2016, p. 1065-1072.

Research output: Contribution to journalArticle

Kocarnik, JM, Chan, AT, Slattery, ML, Potter, JD, Meyerhardt, J, Phipps, A, Nan, H, Harrison, T, Rohan, TE, Qi, L, Hou, L, Caan, B, Kroenke, CH, Strickler, H, Hayes, RB, Schoen, RE, Chong, DQ, White, E, Berndt, SI, Peters, U & Newcomb, PA 2016, 'Relationship of prediagnostic body mass index with survival after colorectal cancer: Stage-specific associations', International Journal of Cancer, vol. 139, no. 5, pp. 1065-1072. https://doi.org/10.1002/ijc.30163
Kocarnik, Jonathan M. ; Chan, Andrew T. ; Slattery, Martha L. ; Potter, John D. ; Meyerhardt, Jeffrey ; Phipps, Amanda ; Nan, Hongmei ; Harrison, Tabitha ; Rohan, Thomas E. ; Qi, Lihong ; Hou, Lifang ; Caan, Bette ; Kroenke, Candyce H. ; Strickler, Howard ; Hayes, Richard B. ; Schoen, Robert E. ; Chong, Dawn Q. ; White, Emily ; Berndt, Sonja I. ; Peters, Ulrike ; Newcomb, Polly A. / Relationship of prediagnostic body mass index with survival after colorectal cancer : Stage-specific associations. In: International Journal of Cancer. 2016 ; Vol. 139, No. 5. pp. 1065-1072.
@article{38e9084930dc40d3b0766838357780b5,
title = "Relationship of prediagnostic body mass index with survival after colorectal cancer: Stage-specific associations",
abstract = "Higher body mass index (BMI) is a well-established risk factor for colorectal cancer (CRC), but is inconsistently associated with CRC survival. In 6 prospective studies participating in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), 2,249 non-Hispanic white CRC cases were followed for a median 4.5 years after diagnosis, during which 777 died, 554 from CRC-related causes. Associations between prediagnosis BMI and survival (overall and CRC-specific) were evaluated using Cox regression models adjusted for age at diagnosis, sex, study and smoking status (current/former/never). The association between BMI category and CRC survival varied by cancer stage at diagnosis (I-IV) for both all-cause (p-interaction = 0.03) and CRC-specific mortality (p-interaction = 0.04). Compared to normal BMI (18.5-24.9 kg/m2), overweight (BMI 25.0-29.9) was associated with increased mortality among those with Stage I disease, and decreased mortality among those with Stages II-IV disease. Similarly, obesity (BMI ≥30) was associated with increased mortality among those with Stages I-II disease, and decreased mortality among those with Stages III-IV disease. These results suggest the relationship between BMI and survival after CRC diagnosis differs by stage at diagnosis, and may emphasize the importance of adequate metabolic reserves for colorectal cancer survival in patients with late-stage disease.",
keywords = "body mass index (BMI), cancer stage, colorectal cancer (CRC), mortality, survival",
author = "Kocarnik, {Jonathan M.} and Chan, {Andrew T.} and Slattery, {Martha L.} and Potter, {John D.} and Jeffrey Meyerhardt and Amanda Phipps and Hongmei Nan and Tabitha Harrison and Rohan, {Thomas E.} and Lihong Qi and Lifang Hou and Bette Caan and Kroenke, {Candyce H.} and Howard Strickler and Hayes, {Richard B.} and Schoen, {Robert E.} and Chong, {Dawn Q.} and Emily White and Berndt, {Sonja I.} and Ulrike Peters and Newcomb, {Polly A.}",
year = "2016",
month = "9",
day = "1",
doi = "10.1002/ijc.30163",
language = "English (US)",
volume = "139",
pages = "1065--1072",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "5",

}

TY - JOUR

T1 - Relationship of prediagnostic body mass index with survival after colorectal cancer

T2 - Stage-specific associations

AU - Kocarnik, Jonathan M.

AU - Chan, Andrew T.

AU - Slattery, Martha L.

AU - Potter, John D.

AU - Meyerhardt, Jeffrey

AU - Phipps, Amanda

AU - Nan, Hongmei

AU - Harrison, Tabitha

AU - Rohan, Thomas E.

AU - Qi, Lihong

AU - Hou, Lifang

AU - Caan, Bette

AU - Kroenke, Candyce H.

AU - Strickler, Howard

AU - Hayes, Richard B.

AU - Schoen, Robert E.

AU - Chong, Dawn Q.

AU - White, Emily

AU - Berndt, Sonja I.

AU - Peters, Ulrike

AU - Newcomb, Polly A.

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Higher body mass index (BMI) is a well-established risk factor for colorectal cancer (CRC), but is inconsistently associated with CRC survival. In 6 prospective studies participating in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), 2,249 non-Hispanic white CRC cases were followed for a median 4.5 years after diagnosis, during which 777 died, 554 from CRC-related causes. Associations between prediagnosis BMI and survival (overall and CRC-specific) were evaluated using Cox regression models adjusted for age at diagnosis, sex, study and smoking status (current/former/never). The association between BMI category and CRC survival varied by cancer stage at diagnosis (I-IV) for both all-cause (p-interaction = 0.03) and CRC-specific mortality (p-interaction = 0.04). Compared to normal BMI (18.5-24.9 kg/m2), overweight (BMI 25.0-29.9) was associated with increased mortality among those with Stage I disease, and decreased mortality among those with Stages II-IV disease. Similarly, obesity (BMI ≥30) was associated with increased mortality among those with Stages I-II disease, and decreased mortality among those with Stages III-IV disease. These results suggest the relationship between BMI and survival after CRC diagnosis differs by stage at diagnosis, and may emphasize the importance of adequate metabolic reserves for colorectal cancer survival in patients with late-stage disease.

AB - Higher body mass index (BMI) is a well-established risk factor for colorectal cancer (CRC), but is inconsistently associated with CRC survival. In 6 prospective studies participating in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), 2,249 non-Hispanic white CRC cases were followed for a median 4.5 years after diagnosis, during which 777 died, 554 from CRC-related causes. Associations between prediagnosis BMI and survival (overall and CRC-specific) were evaluated using Cox regression models adjusted for age at diagnosis, sex, study and smoking status (current/former/never). The association between BMI category and CRC survival varied by cancer stage at diagnosis (I-IV) for both all-cause (p-interaction = 0.03) and CRC-specific mortality (p-interaction = 0.04). Compared to normal BMI (18.5-24.9 kg/m2), overweight (BMI 25.0-29.9) was associated with increased mortality among those with Stage I disease, and decreased mortality among those with Stages II-IV disease. Similarly, obesity (BMI ≥30) was associated with increased mortality among those with Stages I-II disease, and decreased mortality among those with Stages III-IV disease. These results suggest the relationship between BMI and survival after CRC diagnosis differs by stage at diagnosis, and may emphasize the importance of adequate metabolic reserves for colorectal cancer survival in patients with late-stage disease.

KW - body mass index (BMI)

KW - cancer stage

KW - colorectal cancer (CRC)

KW - mortality

KW - survival

UR - http://www.scopus.com/inward/record.url?scp=84969916103&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84969916103&partnerID=8YFLogxK

U2 - 10.1002/ijc.30163

DO - 10.1002/ijc.30163

M3 - Article

C2 - 27121247

AN - SCOPUS:84969916103

VL - 139

SP - 1065

EP - 1072

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 5

ER -