Relationship of weight to successful induction of ovulation with clomiphene citrate

Marguerite Shepard, J. P. Balmaceda, C. G. Leija

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Over a 6.5 yr period, 117 patients who were anovulatory, and estrogen-primed were treated with clomiphene citrate. Graduate doses from 50 mg to 250 mg daily for 5 days were used to induce ovulation. Of 62 patients who completed treatment, 50 ovulated and 12 did not. Several factors, including age, duration of infertility, weight, previous menstrual history, previous pregnancy history, and previous use of oral contraceptives, were investigated to determine conditions which might influence response. Only weight was found to be significantly different between responders and nonresponders. Furthermore, there was a linear relationship between body weight and dose of clomiphene required to induce ovulation. The ovulation rate for those completing therapy was 81% with a pregnancy rate of 76% of the total and 94% of those ovulating. Population homogenity with anovulation as the major cause of infertility appears to be the most plausible explanation for the high pregnancy rate.

Original languageEnglish (US)
Pages (from-to)641-645
Number of pages5
JournalFertility and Sterility
Volume32
Issue number6
StatePublished - 1979
Externally publishedYes

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Clomiphene
Ovulation Induction
Ovulation
Pregnancy Rate
Weights and Measures
Infertility
Anovulation
Reproductive History
Age Factors
Oral Contraceptives
Estrogens
Body Weight
Therapeutics
Population

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Relationship of weight to successful induction of ovulation with clomiphene citrate. / Shepard, Marguerite; Balmaceda, J. P.; Leija, C. G.

In: Fertility and Sterility, Vol. 32, No. 6, 1979, p. 641-645.

Research output: Contribution to journalArticle

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