Relative accuracy and reproducibility of regional MRI brain volumes for point-counting methods

James R. MacFall, Chris E. Byrum, Ioanis Parashos, Bridgett Early, H. Cecil Charles, Venkat Chittilla, Orest B. Boyko, Lucy Upchurch, K. Ranga R. Krishnan

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Volumetric magnetic resonance imaging (MRI) methods for the measurement of various neuroanatomical regions are of great interest in studies of neuropsychiatric disorders. Both manual and semiautomated methods have been developed. Manual methods include tracing and point counting. Point-counting methods are widely used in post-mortem and microscopy studies. Point counting has been well validated for these purposes. In this article, we report in a series of separate studies the accuracy and reproducibility of point-counting methods. Absolute accuracy was evaluated with a spherical phantom. Accuracy and time efficiency were subsequently assessed with an anatomically realistic phantom and various size grids. The point-counting method was also compared to a tracing method. Finally, the reproducibility of the point-counting method for the caudate and putamen was evaluated on four subjects in a test-retest experiment. These studies provide an estimate of the accuracy and time efficiency of point-counting methods. The test-retest reliability was also high for both caudate and putamen. Findings suggest that point counting is a reliable and efficient method for estimating volumes.

Original languageEnglish (US)
Pages (from-to)167-177
Number of pages11
JournalPsychiatry Research: Neuroimaging
Volume55
Issue number3
DOIs
StatePublished - Sep 1994

Fingerprint

Magnetic Resonance Imaging
Brain
Putamen
Reproducibility of Results
Microscopy

Keywords

  • Magnetic resonance imaging
  • caudate
  • neuroanatomy
  • putamen
  • test-retest reliability

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

Cite this

MacFall, J. R., Byrum, C. E., Parashos, I., Early, B., Charles, H. C., Chittilla, V., ... Krishnan, K. R. R. (1994). Relative accuracy and reproducibility of regional MRI brain volumes for point-counting methods. Psychiatry Research: Neuroimaging, 55(3), 167-177. https://doi.org/10.1016/0925-4927(94)90024-8

Relative accuracy and reproducibility of regional MRI brain volumes for point-counting methods. / MacFall, James R.; Byrum, Chris E.; Parashos, Ioanis; Early, Bridgett; Charles, H. Cecil; Chittilla, Venkat; Boyko, Orest B.; Upchurch, Lucy; Krishnan, K. Ranga R.

In: Psychiatry Research: Neuroimaging, Vol. 55, No. 3, 09.1994, p. 167-177.

Research output: Contribution to journalArticle

MacFall, JR, Byrum, CE, Parashos, I, Early, B, Charles, HC, Chittilla, V, Boyko, OB, Upchurch, L & Krishnan, KRR 1994, 'Relative accuracy and reproducibility of regional MRI brain volumes for point-counting methods', Psychiatry Research: Neuroimaging, vol. 55, no. 3, pp. 167-177. https://doi.org/10.1016/0925-4927(94)90024-8
MacFall, James R. ; Byrum, Chris E. ; Parashos, Ioanis ; Early, Bridgett ; Charles, H. Cecil ; Chittilla, Venkat ; Boyko, Orest B. ; Upchurch, Lucy ; Krishnan, K. Ranga R. / Relative accuracy and reproducibility of regional MRI brain volumes for point-counting methods. In: Psychiatry Research: Neuroimaging. 1994 ; Vol. 55, No. 3. pp. 167-177.
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