Reliability of striatal [ 11C]raclopride binding in smokers wearing transdermal nicotine patches

Karmen Yoder, Daniel S. Albrecht, David Kareken, Lauren M. Federici, Kevin M. Perry, Elizabeth A. Patton, Qi-Huang Zheng, Bruce H. Mock, Sean O'Connor, Christine M. Herring

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: In studies where [ 11C]raclopride (RAC) positron emission tomography (PET) is used to assess changes in striatal dopamine, it is important to control for cognitive states, such as drug craving, that could alter dopamine levels. In cigarette smokers, transdermal nicotine patches (TNP) can control nicotine craving, but the effects of nicotine patches on RAC binding are unknown. Thus, we sought to determine the test-retest reliability of RAC binding in the presence of nicotine patches. Methods: Eleven male smokers were scanned twice with RAC on separate days while wearing TNP. Results: Across the striatum, test-retest variability was 7.63±5.88; percent change in binding potential was 1.11±9.83; and the intraclass correlation coefficient was 0.91 (p<0.0001). Conclusion: Baseline RAC binding is highly reproducible in smokers wearing nicotine patches. This suggests that TNP are an acceptable method for controlling cigarette craving during studies that utilize RAC to examine changes in dopamine.

Original languageEnglish
Pages (from-to)220-225
Number of pages6
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume39
Issue number2
DOIs
StatePublished - Feb 2012

Fingerprint

Tobacco Use Cessation Products
Raclopride
Corpus Striatum
Dopamine
Tobacco Products
Nicotine
Reproducibility of Results
Positron-Emission Tomography
Pharmaceutical Preparations
Craving

Keywords

  • [ C]raclopride
  • D receptor
  • Dopamine
  • Positron emission tomography
  • Test-retest variability
  • Transdermal nicotine patch

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Reliability of striatal [ 11C]raclopride binding in smokers wearing transdermal nicotine patches. / Yoder, Karmen; Albrecht, Daniel S.; Kareken, David; Federici, Lauren M.; Perry, Kevin M.; Patton, Elizabeth A.; Zheng, Qi-Huang; Mock, Bruce H.; O'Connor, Sean; Herring, Christine M.

In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 39, No. 2, 02.2012, p. 220-225.

Research output: Contribution to journalArticle

Yoder, Karmen ; Albrecht, Daniel S. ; Kareken, David ; Federici, Lauren M. ; Perry, Kevin M. ; Patton, Elizabeth A. ; Zheng, Qi-Huang ; Mock, Bruce H. ; O'Connor, Sean ; Herring, Christine M. / Reliability of striatal [ 11C]raclopride binding in smokers wearing transdermal nicotine patches. In: European Journal of Nuclear Medicine and Molecular Imaging. 2012 ; Vol. 39, No. 2. pp. 220-225.
@article{619b3d56d3c141ba93c1ca90017f4c38,
title = "Reliability of striatal [ 11C]raclopride binding in smokers wearing transdermal nicotine patches",
abstract = "Purpose: In studies where [ 11C]raclopride (RAC) positron emission tomography (PET) is used to assess changes in striatal dopamine, it is important to control for cognitive states, such as drug craving, that could alter dopamine levels. In cigarette smokers, transdermal nicotine patches (TNP) can control nicotine craving, but the effects of nicotine patches on RAC binding are unknown. Thus, we sought to determine the test-retest reliability of RAC binding in the presence of nicotine patches. Methods: Eleven male smokers were scanned twice with RAC on separate days while wearing TNP. Results: Across the striatum, test-retest variability was 7.63±5.88; percent change in binding potential was 1.11±9.83; and the intraclass correlation coefficient was 0.91 (p<0.0001). Conclusion: Baseline RAC binding is highly reproducible in smokers wearing nicotine patches. This suggests that TNP are an acceptable method for controlling cigarette craving during studies that utilize RAC to examine changes in dopamine.",
keywords = "[ C]raclopride, D receptor, Dopamine, Positron emission tomography, Test-retest variability, Transdermal nicotine patch",
author = "Karmen Yoder and Albrecht, {Daniel S.} and David Kareken and Federici, {Lauren M.} and Perry, {Kevin M.} and Patton, {Elizabeth A.} and Qi-Huang Zheng and Mock, {Bruce H.} and Sean O'Connor and Herring, {Christine M.}",
year = "2012",
month = "2",
doi = "10.1007/s00259-011-1965-z",
language = "English",
volume = "39",
pages = "220--225",
journal = "European Journal of Nuclear Medicine and Molecular Imaging",
issn = "1619-7070",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - Reliability of striatal [ 11C]raclopride binding in smokers wearing transdermal nicotine patches

AU - Yoder, Karmen

AU - Albrecht, Daniel S.

AU - Kareken, David

AU - Federici, Lauren M.

AU - Perry, Kevin M.

AU - Patton, Elizabeth A.

AU - Zheng, Qi-Huang

AU - Mock, Bruce H.

AU - O'Connor, Sean

AU - Herring, Christine M.

PY - 2012/2

Y1 - 2012/2

N2 - Purpose: In studies where [ 11C]raclopride (RAC) positron emission tomography (PET) is used to assess changes in striatal dopamine, it is important to control for cognitive states, such as drug craving, that could alter dopamine levels. In cigarette smokers, transdermal nicotine patches (TNP) can control nicotine craving, but the effects of nicotine patches on RAC binding are unknown. Thus, we sought to determine the test-retest reliability of RAC binding in the presence of nicotine patches. Methods: Eleven male smokers were scanned twice with RAC on separate days while wearing TNP. Results: Across the striatum, test-retest variability was 7.63±5.88; percent change in binding potential was 1.11±9.83; and the intraclass correlation coefficient was 0.91 (p<0.0001). Conclusion: Baseline RAC binding is highly reproducible in smokers wearing nicotine patches. This suggests that TNP are an acceptable method for controlling cigarette craving during studies that utilize RAC to examine changes in dopamine.

AB - Purpose: In studies where [ 11C]raclopride (RAC) positron emission tomography (PET) is used to assess changes in striatal dopamine, it is important to control for cognitive states, such as drug craving, that could alter dopamine levels. In cigarette smokers, transdermal nicotine patches (TNP) can control nicotine craving, but the effects of nicotine patches on RAC binding are unknown. Thus, we sought to determine the test-retest reliability of RAC binding in the presence of nicotine patches. Methods: Eleven male smokers were scanned twice with RAC on separate days while wearing TNP. Results: Across the striatum, test-retest variability was 7.63±5.88; percent change in binding potential was 1.11±9.83; and the intraclass correlation coefficient was 0.91 (p<0.0001). Conclusion: Baseline RAC binding is highly reproducible in smokers wearing nicotine patches. This suggests that TNP are an acceptable method for controlling cigarette craving during studies that utilize RAC to examine changes in dopamine.

KW - [ C]raclopride

KW - D receptor

KW - Dopamine

KW - Positron emission tomography

KW - Test-retest variability

KW - Transdermal nicotine patch

UR - http://www.scopus.com/inward/record.url?scp=84859651481&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84859651481&partnerID=8YFLogxK

U2 - 10.1007/s00259-011-1965-z

DO - 10.1007/s00259-011-1965-z

M3 - Article

C2 - 22009382

AN - SCOPUS:84859651481

VL - 39

SP - 220

EP - 225

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

SN - 1619-7070

IS - 2

ER -