Remineralisation effect of a dual-phase calcium silicate/phosphate gel combined with calcium silicate/phosphate toothpaste on acid-challenged enamel in situ

Andrew Joiner, Fred Schäfer, Mojgan M. Naeeni, Ashok K. Gupta, Domenick Zero

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objectives To test if a novel dual-phase gel system (calcium silicate and phosphate with 1450 ppm F, as NaF/MFP; TG) combined with a toothpaste (calcium silicate and sodium phosphate with 1450 ppm F, as MFP; TG) was able to re-harden previously acid-challenged enamel to a greater extent than other toothpastes. Methods The study consisted of a double-blind, randomised, cross-over design with four 7-day treatment legs. In each leg, subjects wearing a partial denture holding four demineralised enamel specimens (25 min in 0.3% citric acid, pH 3.8) used either the test regimen (TG + TP) or one of the three controls. (placebo TG + TP; Positive Control - placebo TG + marketed 1450 ppm F toothpaste; Negative Control - placebo TG + placebo TP). Enamel specimens were removed after 1, 2, 3 and 7 days. The gel systems were applied once per day for the first three days during which subjects also brushed with the corresponding toothpaste; this was followed by four days use of the toothpastes only. Toothpastes were used in the conventional way brushing twice per day throughout the seven days. The outcome variable was %Surface Microhardness Recovery calculated after three and seven days of in situ treatment. Results The results showed a statistically significant (p <0.001) re-hardening effect for all treatments compared to pre-treatment hardness. After three days and after seven days of in situ treatment significantly greater hardening (p <0.05) was found in the samples treated with calcium silicate/phosphate gel system plus calcium silicate/phosphate toothpaste than in the control groups. Conclusions It is concluded that the test regimen based on the novel dual-phase gel system combined with toothpaste was able to re-harden acid-challenged tooth enamel to a greater extent than a normal fluoride toothpaste. Clinical Significance The novel oral care products containing calcium silicate, sodium phosphate salts and fluoride is a new approach to the repair of demineralised enamel.

Original languageEnglish (US)
Pages (from-to)S53-S59
JournalJournal of Dentistry
Volume42
DOIs
StatePublished - 2014

Fingerprint

Toothpastes
Dental Enamel
Gels
Acids
Placebos
Leg
Partial Denture
Therapeutics
calcium phosphate
Sodium Fluoride
Hardness
Fluorides
Citric Acid
Cross-Over Studies
Tooth
Salts
Control Groups

Keywords

  • Calcium
  • Enamel
  • Erosion
  • Phosphate
  • Remineralisation

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

Remineralisation effect of a dual-phase calcium silicate/phosphate gel combined with calcium silicate/phosphate toothpaste on acid-challenged enamel in situ. / Joiner, Andrew; Schäfer, Fred; Naeeni, Mojgan M.; Gupta, Ashok K.; Zero, Domenick.

In: Journal of Dentistry, Vol. 42, 2014, p. S53-S59.

Research output: Contribution to journalArticle

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abstract = "Objectives To test if a novel dual-phase gel system (calcium silicate and phosphate with 1450 ppm F, as NaF/MFP; TG) combined with a toothpaste (calcium silicate and sodium phosphate with 1450 ppm F, as MFP; TG) was able to re-harden previously acid-challenged enamel to a greater extent than other toothpastes. Methods The study consisted of a double-blind, randomised, cross-over design with four 7-day treatment legs. In each leg, subjects wearing a partial denture holding four demineralised enamel specimens (25 min in 0.3{\%} citric acid, pH 3.8) used either the test regimen (TG + TP) or one of the three controls. (placebo TG + TP; Positive Control - placebo TG + marketed 1450 ppm F toothpaste; Negative Control - placebo TG + placebo TP). Enamel specimens were removed after 1, 2, 3 and 7 days. The gel systems were applied once per day for the first three days during which subjects also brushed with the corresponding toothpaste; this was followed by four days use of the toothpastes only. Toothpastes were used in the conventional way brushing twice per day throughout the seven days. The outcome variable was {\%}Surface Microhardness Recovery calculated after three and seven days of in situ treatment. Results The results showed a statistically significant (p <0.001) re-hardening effect for all treatments compared to pre-treatment hardness. After three days and after seven days of in situ treatment significantly greater hardening (p <0.05) was found in the samples treated with calcium silicate/phosphate gel system plus calcium silicate/phosphate toothpaste than in the control groups. Conclusions It is concluded that the test regimen based on the novel dual-phase gel system combined with toothpaste was able to re-harden acid-challenged tooth enamel to a greater extent than a normal fluoride toothpaste. Clinical Significance The novel oral care products containing calcium silicate, sodium phosphate salts and fluoride is a new approach to the repair of demineralised enamel.",
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AU - Gupta, Ashok K.

AU - Zero, Domenick

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N2 - Objectives To test if a novel dual-phase gel system (calcium silicate and phosphate with 1450 ppm F, as NaF/MFP; TG) combined with a toothpaste (calcium silicate and sodium phosphate with 1450 ppm F, as MFP; TG) was able to re-harden previously acid-challenged enamel to a greater extent than other toothpastes. Methods The study consisted of a double-blind, randomised, cross-over design with four 7-day treatment legs. In each leg, subjects wearing a partial denture holding four demineralised enamel specimens (25 min in 0.3% citric acid, pH 3.8) used either the test regimen (TG + TP) or one of the three controls. (placebo TG + TP; Positive Control - placebo TG + marketed 1450 ppm F toothpaste; Negative Control - placebo TG + placebo TP). Enamel specimens were removed after 1, 2, 3 and 7 days. The gel systems were applied once per day for the first three days during which subjects also brushed with the corresponding toothpaste; this was followed by four days use of the toothpastes only. Toothpastes were used in the conventional way brushing twice per day throughout the seven days. The outcome variable was %Surface Microhardness Recovery calculated after three and seven days of in situ treatment. Results The results showed a statistically significant (p <0.001) re-hardening effect for all treatments compared to pre-treatment hardness. After three days and after seven days of in situ treatment significantly greater hardening (p <0.05) was found in the samples treated with calcium silicate/phosphate gel system plus calcium silicate/phosphate toothpaste than in the control groups. Conclusions It is concluded that the test regimen based on the novel dual-phase gel system combined with toothpaste was able to re-harden acid-challenged tooth enamel to a greater extent than a normal fluoride toothpaste. Clinical Significance The novel oral care products containing calcium silicate, sodium phosphate salts and fluoride is a new approach to the repair of demineralised enamel.

AB - Objectives To test if a novel dual-phase gel system (calcium silicate and phosphate with 1450 ppm F, as NaF/MFP; TG) combined with a toothpaste (calcium silicate and sodium phosphate with 1450 ppm F, as MFP; TG) was able to re-harden previously acid-challenged enamel to a greater extent than other toothpastes. Methods The study consisted of a double-blind, randomised, cross-over design with four 7-day treatment legs. In each leg, subjects wearing a partial denture holding four demineralised enamel specimens (25 min in 0.3% citric acid, pH 3.8) used either the test regimen (TG + TP) or one of the three controls. (placebo TG + TP; Positive Control - placebo TG + marketed 1450 ppm F toothpaste; Negative Control - placebo TG + placebo TP). Enamel specimens were removed after 1, 2, 3 and 7 days. The gel systems were applied once per day for the first three days during which subjects also brushed with the corresponding toothpaste; this was followed by four days use of the toothpastes only. Toothpastes were used in the conventional way brushing twice per day throughout the seven days. The outcome variable was %Surface Microhardness Recovery calculated after three and seven days of in situ treatment. Results The results showed a statistically significant (p <0.001) re-hardening effect for all treatments compared to pre-treatment hardness. After three days and after seven days of in situ treatment significantly greater hardening (p <0.05) was found in the samples treated with calcium silicate/phosphate gel system plus calcium silicate/phosphate toothpaste than in the control groups. Conclusions It is concluded that the test regimen based on the novel dual-phase gel system combined with toothpaste was able to re-harden acid-challenged tooth enamel to a greater extent than a normal fluoride toothpaste. Clinical Significance The novel oral care products containing calcium silicate, sodium phosphate salts and fluoride is a new approach to the repair of demineralised enamel.

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KW - Erosion

KW - Phosphate

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