This report describes a patient with an invasive epidermoid carcinoma of the tongue who presented with insulin-requiring diabetes mellitus. Fasting blood glucose 379 mg/dl and 295 mg/dl on two successive days. The patient required 35 to 40 units of insulin per day for control. After removal of the carcinoma of the insulin requirements decreased, and ultimately the insulin was stopped. One year after removal of the carcinoma, glucose and insulin levels were completely normal during an oral glucose tolerance test, demonstrating complete remission of overt diabetes mellitus.
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