Remodeling of Mineralized Tissues, Part II: Control and Pathophysiology

W. Eugene Roberts, Bruce N. Epker, David B. Burr, James K. Hartsfield, Jeffery A. Roberts

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Based on a review of literature, the bone remodeling concepts, as defined by Harold Frost, are extended to the molecular level to help explain common bone physiopathology. Remodeling of mineralized tissue is an inflammatory response to accumulated tissue damage. Inflammation activates (A) the localized cell population, which attracts circulating osteoclast precursors, and initiates foci of vascular invasion. Coordination of these cybernetic events results in formation of a cutting/filling cone (cortical bone) or a hemicutting/filling cone (trabecular bone). Damaged bone is resorbed (R) creating a self-limited resorption cavity that is then filled by bone formation (F). A genetic mechanism (RANK/RANKL/OPG) is proposed for coupling bone formation to resorption during the remodeling process. Following surgery and/or initiation of orthodontic tooth movement, a regional acceleratory response (RAP) occurs throughout the affected alveolar process. Undermining resorption during the initial stage of tooth movement is analogous to initiation of a bone remodeling cycle (A→R→F). Understanding the cell dynamics of the ARF sequence is fundamental for appreciating common remodeling disorders such as osteoporosis, Paget's disease, hypo- and hyperparathyroidism, metastases, and external apical root resorption. Depending on the physiopathologic context, remodeling may enhance or limit the orthodontic options for management of a malocclusion.

Original languageEnglish (US)
Pages (from-to)238-253
Number of pages16
JournalSeminars in Orthodontics
Volume12
Issue number4
DOIs
StatePublished - Dec 1 2006

Fingerprint

Tooth Movement Techniques
Bone Remodeling
Osteogenesis
Cybernetics
Root Resorption
Alveolar Process
Bone and Bones
Hypoparathyroidism
Malocclusion
Hyperparathyroidism
Osteoclasts
Orthodontics
Osteoporosis
Blood Vessels
Neoplasm Metastasis
Inflammation
Population
Cortical Bone
Cancellous Bone

ASJC Scopus subject areas

  • Orthodontics

Cite this

Roberts, W. E., Epker, B. N., Burr, D. B., Hartsfield, J. K., & Roberts, J. A. (2006). Remodeling of Mineralized Tissues, Part II: Control and Pathophysiology. Seminars in Orthodontics, 12(4), 238-253. https://doi.org/10.1053/j.sodo.2006.08.003

Remodeling of Mineralized Tissues, Part II : Control and Pathophysiology. / Roberts, W. Eugene; Epker, Bruce N.; Burr, David B.; Hartsfield, James K.; Roberts, Jeffery A.

In: Seminars in Orthodontics, Vol. 12, No. 4, 01.12.2006, p. 238-253.

Research output: Contribution to journalArticle

Roberts, WE, Epker, BN, Burr, D, Hartsfield, JK & Roberts, JA 2006, 'Remodeling of Mineralized Tissues, Part II: Control and Pathophysiology', Seminars in Orthodontics, vol. 12, no. 4, pp. 238-253. https://doi.org/10.1053/j.sodo.2006.08.003
Roberts, W. Eugene ; Epker, Bruce N. ; Burr, David B. ; Hartsfield, James K. ; Roberts, Jeffery A. / Remodeling of Mineralized Tissues, Part II : Control and Pathophysiology. In: Seminars in Orthodontics. 2006 ; Vol. 12, No. 4. pp. 238-253.
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