Remote magnetic control of autophagy in mouse b-lymphoma cells with iron oxide nanoparticles

You Rong Lin, Chia Hao Chan, Hui Ting Lee, Sheng Jen Cheng, Jia Wei Yang, Shing Jyh Chang, Shien-Fong Lin, Guan Yu Chen

Research output: Contribution to journalArticle

Abstract

Autophagy is the spontaneous degradation of intracellular proteins and organelles in response to nutrient deprivation. The phagocytosis of iron oxide nanoparticles (IONPs) results in intracellular degradation that can be exploited for use in cancer treatment. Non-invasive magnetic control has emerged as an important technology, with breakthroughs achieved in areas such as magneto-thermal therapy and drug delivery. This study aimed to regulate autophagy in mouse B-lymphoma cells (A20) through the incorporation of IONPs-quantum dots (QDs). We hypothesized that with the application of an external magnetic field after phagocytosis of IONPs-QDs, autophagy of intracellular IONPs-QDs could be regulated in a non-invasive manner and subsequently modulate the regulation of inflammatory responses. The potential of this approach as a cancer treatment method was explored. The application of IONPs and an external magnetic force enabled the non-invasive regulation of cell autophagy and modulation of the self-regulatory function of cells. The combination of non-invasive magnetic fields and nanotechnology could provide a new approach to cancer treatment.

Original languageEnglish (US)
Article number551
JournalNanomaterials
Volume9
Issue number4
DOIs
StatePublished - Apr 1 2019
Externally publishedYes

Fingerprint

Iron oxides
Oncology
Nanoparticles
Semiconductor quantum dots
Magnetic fields
Degradation
Drug delivery
Nanotechnology
Nutrients
Cells
Modulation
ferric oxide
Proteins

Keywords

  • Autophagy
  • Iron oxide nanoparticle
  • Magnetic field
  • Proinflammatory cytokine

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Materials Science(all)

Cite this

Lin, Y. R., Chan, C. H., Lee, H. T., Cheng, S. J., Yang, J. W., Chang, S. J., ... Chen, G. Y. (2019). Remote magnetic control of autophagy in mouse b-lymphoma cells with iron oxide nanoparticles. Nanomaterials, 9(4), [551]. https://doi.org/10.3390/nano9040551

Remote magnetic control of autophagy in mouse b-lymphoma cells with iron oxide nanoparticles. / Lin, You Rong; Chan, Chia Hao; Lee, Hui Ting; Cheng, Sheng Jen; Yang, Jia Wei; Chang, Shing Jyh; Lin, Shien-Fong; Chen, Guan Yu.

In: Nanomaterials, Vol. 9, No. 4, 551, 01.04.2019.

Research output: Contribution to journalArticle

Lin, YR, Chan, CH, Lee, HT, Cheng, SJ, Yang, JW, Chang, SJ, Lin, S-F & Chen, GY 2019, 'Remote magnetic control of autophagy in mouse b-lymphoma cells with iron oxide nanoparticles', Nanomaterials, vol. 9, no. 4, 551. https://doi.org/10.3390/nano9040551
Lin, You Rong ; Chan, Chia Hao ; Lee, Hui Ting ; Cheng, Sheng Jen ; Yang, Jia Wei ; Chang, Shing Jyh ; Lin, Shien-Fong ; Chen, Guan Yu. / Remote magnetic control of autophagy in mouse b-lymphoma cells with iron oxide nanoparticles. In: Nanomaterials. 2019 ; Vol. 9, No. 4.
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