Renal blood flow in sepsis: A complex issue

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The clinical complexity of sepsis and the regional variability in renal blood flow present a difficult challenge for the clinician or investigator in understanding the role and clinical importance of reduced blood flow in the pathophysiology of sepsis-induced acute renal failure. Understanding the role of regional microvasculature flow and interactions between endothelium and white blood cells in the local delivery of oxygen and substrates is of critical importance. Therefore, measuring total renal blood flow may not permit an adequate understanding of the role of altered hemodynamics in septic patients who develop acute renal failure.

Original languageEnglish
Pages (from-to)327-328
Number of pages2
JournalCritical Care
Volume9
Issue number4
DOIs
StatePublished - Aug 2005

Fingerprint

Renal Circulation
Acute Kidney Injury
Sepsis
Microvessels
Endothelium
Leukocytes
Hemodynamics
Research Personnel
Oxygen

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Renal blood flow in sepsis : A complex issue. / Molitoris, Bruce.

In: Critical Care, Vol. 9, No. 4, 08.2005, p. 327-328.

Research output: Contribution to journalArticle

@article{8d3ebe96e8e8409ebe059093020f4a25,
title = "Renal blood flow in sepsis: A complex issue",
abstract = "The clinical complexity of sepsis and the regional variability in renal blood flow present a difficult challenge for the clinician or investigator in understanding the role and clinical importance of reduced blood flow in the pathophysiology of sepsis-induced acute renal failure. Understanding the role of regional microvasculature flow and interactions between endothelium and white blood cells in the local delivery of oxygen and substrates is of critical importance. Therefore, measuring total renal blood flow may not permit an adequate understanding of the role of altered hemodynamics in septic patients who develop acute renal failure.",
author = "Bruce Molitoris",
year = "2005",
month = "8",
doi = "10.1186/cc3740",
language = "English",
volume = "9",
pages = "327--328",
journal = "Critical Care",
issn = "1466-609X",
publisher = "Springer Science + Business Media",
number = "4",

}

TY - JOUR

T1 - Renal blood flow in sepsis

T2 - A complex issue

AU - Molitoris, Bruce

PY - 2005/8

Y1 - 2005/8

N2 - The clinical complexity of sepsis and the regional variability in renal blood flow present a difficult challenge for the clinician or investigator in understanding the role and clinical importance of reduced blood flow in the pathophysiology of sepsis-induced acute renal failure. Understanding the role of regional microvasculature flow and interactions between endothelium and white blood cells in the local delivery of oxygen and substrates is of critical importance. Therefore, measuring total renal blood flow may not permit an adequate understanding of the role of altered hemodynamics in septic patients who develop acute renal failure.

AB - The clinical complexity of sepsis and the regional variability in renal blood flow present a difficult challenge for the clinician or investigator in understanding the role and clinical importance of reduced blood flow in the pathophysiology of sepsis-induced acute renal failure. Understanding the role of regional microvasculature flow and interactions between endothelium and white blood cells in the local delivery of oxygen and substrates is of critical importance. Therefore, measuring total renal blood flow may not permit an adequate understanding of the role of altered hemodynamics in septic patients who develop acute renal failure.

UR - http://www.scopus.com/inward/record.url?scp=23744476935&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23744476935&partnerID=8YFLogxK

U2 - 10.1186/cc3740

DO - 10.1186/cc3740

M3 - Article

C2 - 16137373

AN - SCOPUS:23744476935

VL - 9

SP - 327

EP - 328

JO - Critical Care

JF - Critical Care

SN - 1466-609X

IS - 4

ER -