Renal endothelial dysfunction in acute kidney ischemia reperfusion injury

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

Acute kidney injury is associated with alterations in vascular tone that contribute to an overall reduction in GFR. Studies in animal models indicate that ischemia triggers alterations in endothelial function that contribute significantly to the overall degree and severity of a kidney injury. Putative mediators of vasoconstriction that may contribute to the initial loss of renal blood flow and GFR are highlighted. In addition, there is discussion of how intrinsic damage to the endothelium impairs homeostatic responses in vascular tone as well as promotes leukocyte adhesion and exacerbating the reduction in renal blood flow. The timing of potential therapies in animal models as they relate to the evolution of AKI, as well as the limitations of such approaches in the clinical setting are discussed. Finally, we discuss how acute kidney injury induces permanent alterations in renal vascular structure. We posit that the cause of the sustained impairment in kidney capillary density results from impaired endothelial growth responses and suggest that this limitation is a primary contributing feature underlying progression of chronic kidney disease.

Original languageEnglish (US)
Pages (from-to)3-14
Number of pages12
JournalCardiovascular and Hematological Disorders - Drug Targets
Volume14
Issue number1
DOIs
StatePublished - Jan 1 2014

Keywords

  • Angiogenesis
  • Chronic kidney disease
  • Inflammation
  • Rarefaction
  • Repair

ASJC Scopus subject areas

  • Molecular Medicine
  • Cardiology and Cardiovascular Medicine
  • Hematology
  • Pharmacology

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