Renal Endothelial Injury and Microvascular Dysfunction in Acute Kidney Injury

Sudhanshu Kumar Verma, Bruce A. Molitoris

Research output: Contribution to journalReview article

59 Scopus citations

Abstract

The kidney is comprised of heterogeneous cell populations that function together to perform a number of tightly controlled, complex and interdependent processes. Renal endothelial cells contribute to vascular tone, regulation of blood flow to local tissue beds, modulation of coagulation and inflammation, and vascular permeability. Both ischemia and sepsis have profound effects on the renal endothelium, resulting in microvascular dysregulation resulting in continued ischemia and further injury. In recent years, the concept of the vascular endothelium as an organ that is both the source of and target for inflammatory injury has become widely appreciated. Here we revisit the renal endothelium in the light of ever evolving molecular advances.

Original languageEnglish (US)
Pages (from-to)96-107
Number of pages12
JournalSeminars in Nephrology
Volume35
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • AKI
  • Endothelium
  • Kidney

ASJC Scopus subject areas

  • Nephrology

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