Renal epithelial polarity in health and disease

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Epithelial cells mediate the unidirectional movement of selective compounds from one biological compartment to another. This is accomplished by having biochemically, structurally, and functionally distinctive apical and basolateral surface membrane domains separated by the cells' junctional complex. Derangement of this highly ordered situation can result in cell injury, dysfunction, and even death. For renal epithelial cells, both ischemia and polycystic kidney disease are known to result in a loss of surface membrane polarity. In both disease processes, this in turn plays an important role in cell and organ dysfunction.

Original languageEnglish
Pages (from-to)163-170
Number of pages8
JournalPediatric Nephrology
Volume13
Issue number2
DOIs
StatePublished - Feb 1999

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Kidney
Health
Epithelial Cells
Polycystic Kidney Diseases
Membranes
Ischemia
Wounds and Injuries

Keywords

  • Cytoskeleton
  • Epithelial polarity
  • Ischemia
  • Polycystic kidney disease

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Cite this

Renal epithelial polarity in health and disease. / Wagner, Mark; Molitoris, Bruce.

In: Pediatric Nephrology, Vol. 13, No. 2, 02.1999, p. 163-170.

Research output: Contribution to journalArticle

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