Renal Function in Patients With Nephrolithiasis

Elaine M. Worcester, Joan H. Parks, Andrew Evan, Fredric L. Coe

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Purpose: We describe kidney function, as measured by creatinine clearance in stone formers, and classified by type of stone formed and systemic etiologies of stone formation. Materials and Methods: The mean of 3 pretreatment 24-hour creatinine clearance measurements in each of 1,856 stone formers and creatinine clearance in 153 normal individuals were used. Clearance was adjusted for patient sex, age and body weight using general linear modeling. Results: As a group, all stone formers had decreased clearance adjusted for age, sex and body weight compared to that in normal individuals. Although clearance was particularly low in cystine and struvite stone formers, they were below normal in even common CaOx stone formers. Conclusions: As a rule, patients with kidney stones do not have normal kidney function. In clinical management all efforts must be made to minimize renal injury, balancing the risks of obstruction from stones against those of urological procedures.

Original languageEnglish
Pages (from-to)600-603
Number of pages4
JournalJournal of Urology
Volume176
Issue number2
DOIs
StatePublished - Aug 2006

Fingerprint

Nephrolithiasis
Creatinine
Kidney
Body Weight
Kidney Calculi
Cystine
Wounds and Injuries

Keywords

  • creatinine
  • etiology
  • kidney
  • kidney calculi

ASJC Scopus subject areas

  • Urology

Cite this

Renal Function in Patients With Nephrolithiasis. / Worcester, Elaine M.; Parks, Joan H.; Evan, Andrew; Coe, Fredric L.

In: Journal of Urology, Vol. 176, No. 2, 08.2006, p. 600-603.

Research output: Contribution to journalArticle

Worcester, Elaine M. ; Parks, Joan H. ; Evan, Andrew ; Coe, Fredric L. / Renal Function in Patients With Nephrolithiasis. In: Journal of Urology. 2006 ; Vol. 176, No. 2. pp. 600-603.
@article{ba3bb09895674381b23a066fdc9dcf34,
title = "Renal Function in Patients With Nephrolithiasis",
abstract = "Purpose: We describe kidney function, as measured by creatinine clearance in stone formers, and classified by type of stone formed and systemic etiologies of stone formation. Materials and Methods: The mean of 3 pretreatment 24-hour creatinine clearance measurements in each of 1,856 stone formers and creatinine clearance in 153 normal individuals were used. Clearance was adjusted for patient sex, age and body weight using general linear modeling. Results: As a group, all stone formers had decreased clearance adjusted for age, sex and body weight compared to that in normal individuals. Although clearance was particularly low in cystine and struvite stone formers, they were below normal in even common CaOx stone formers. Conclusions: As a rule, patients with kidney stones do not have normal kidney function. In clinical management all efforts must be made to minimize renal injury, balancing the risks of obstruction from stones against those of urological procedures.",
keywords = "creatinine, etiology, kidney, kidney calculi",
author = "Worcester, {Elaine M.} and Parks, {Joan H.} and Andrew Evan and Coe, {Fredric L.}",
year = "2006",
month = "8",
doi = "10.1016/j.juro.2006.03.095",
language = "English",
volume = "176",
pages = "600--603",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Renal Function in Patients With Nephrolithiasis

AU - Worcester, Elaine M.

AU - Parks, Joan H.

AU - Evan, Andrew

AU - Coe, Fredric L.

PY - 2006/8

Y1 - 2006/8

N2 - Purpose: We describe kidney function, as measured by creatinine clearance in stone formers, and classified by type of stone formed and systemic etiologies of stone formation. Materials and Methods: The mean of 3 pretreatment 24-hour creatinine clearance measurements in each of 1,856 stone formers and creatinine clearance in 153 normal individuals were used. Clearance was adjusted for patient sex, age and body weight using general linear modeling. Results: As a group, all stone formers had decreased clearance adjusted for age, sex and body weight compared to that in normal individuals. Although clearance was particularly low in cystine and struvite stone formers, they were below normal in even common CaOx stone formers. Conclusions: As a rule, patients with kidney stones do not have normal kidney function. In clinical management all efforts must be made to minimize renal injury, balancing the risks of obstruction from stones against those of urological procedures.

AB - Purpose: We describe kidney function, as measured by creatinine clearance in stone formers, and classified by type of stone formed and systemic etiologies of stone formation. Materials and Methods: The mean of 3 pretreatment 24-hour creatinine clearance measurements in each of 1,856 stone formers and creatinine clearance in 153 normal individuals were used. Clearance was adjusted for patient sex, age and body weight using general linear modeling. Results: As a group, all stone formers had decreased clearance adjusted for age, sex and body weight compared to that in normal individuals. Although clearance was particularly low in cystine and struvite stone formers, they were below normal in even common CaOx stone formers. Conclusions: As a rule, patients with kidney stones do not have normal kidney function. In clinical management all efforts must be made to minimize renal injury, balancing the risks of obstruction from stones against those of urological procedures.

KW - creatinine

KW - etiology

KW - kidney

KW - kidney calculi

UR - http://www.scopus.com/inward/record.url?scp=33745282677&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745282677&partnerID=8YFLogxK

U2 - 10.1016/j.juro.2006.03.095

DO - 10.1016/j.juro.2006.03.095

M3 - Article

C2 - 16813897

AN - SCOPUS:33745282677

VL - 176

SP - 600

EP - 603

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 2

ER -