Renal manifestations of systemic diseases

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Abstract

During childhood, the kidney may be involved in several different systemic diseases including the vasculitic syndromes, collagen vascular diseases, and the thrombotic microangiopathic diseases. This article discusses three of the more common systemic disease including Henoch Schonlein Purpura (HSP), systemic lupus erythematosus (SLE), and the hemolytic uremic syndrome (HUS), which occur during childhood. Each of these diseases have important renal manifestations that may present with hematuria with or without proteinuria, hypertension, rapidly progressive glomerulonephritis, and/or with acute renal failure. The occurrence of these diseases during childhood raises lifelong concerns for the child's renal function. As in glomerulonephritis associated with SLE, reactivation of the underlying disease can result in additional renal injury, whereas late extrarenal and renal complications may be observed following HUS or nephritis associated with HSP. These diseases are not only an important cause of acquired chronic renal failure during childhood, but may also lead to end- stage renal disease or other complications that do not become apparent until adulthood. In each disease, we will review the clinical manifestations, the pathology, pathophysiology, and current management and therapy.

Original languageEnglish
Pages (from-to)270-279
Number of pages10
JournalSeminars in Nephrology
Volume18
Issue number3
StatePublished - 1998

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Kidney
Schoenlein-Henoch Purpura
Hemolytic-Uremic Syndrome
Glomerulonephritis
Systemic Lupus Erythematosus
Chronic Kidney Failure
Collagen Diseases
Clinical Pathology
Nephritis
Hematuria
Vascular Diseases
Proteinuria
Acute Kidney Injury
Hypertension
Wounds and Injuries

ASJC Scopus subject areas

  • Nephrology

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Renal manifestations of systemic diseases. / Andreoli, Sharon.

In: Seminars in Nephrology, Vol. 18, No. 3, 1998, p. 270-279.

Research output: Contribution to journalArticle

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