Renal osteodystrophy and chronic kidney disease-mineral bone disorder

Sharon M. Moe, Thomas L. Nickolas

Research output: Chapter in Book/Report/Conference proceedingChapter


Chronic kidney disease (CKD) affects over 20 million individuals in the United States, and 752 million individuals worldwide. Progressive kidney disease that leads to the need for dialysis (end-stage kidney disease) or transplantation affects over 700,000 individuals in the United States. CKD is defined as abnormalities of kidney structure or function present for >3 months, with stratification based on estimated glomerular filtration rate category and the magnitude of albuminuria. The Kidney Disease: Improving Global Outcomes group has updated the classification of CKD and changed the term “stage” to “grade,” as not all kidney disease is progressive, and noted that the presence or absence of albuminuria can greatly influence prognosis. There is considerable overlap between individuals identified with osteoporosis and CKD, and at every stage/grade of kidney disease, there is increased fracture risk, demonstrating the important contribution of CKD to bone fragility.

Original languageEnglish (US)
Title of host publicationPrinciples of Bone Biology
Number of pages25
ISBN (Electronic)9780128148419
StatePublished - Jan 1 2019


  • Bone abnormalities
  • Bone biomarkers
  • Chronic kidney disease
  • Disease classification
  • Mineral bone disorder
  • Renal osteodystrophy
  • Vascular calcification

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • Cite this

    Moe, S. M., & Nickolas, T. L. (2019). Renal osteodystrophy and chronic kidney disease-mineral bone disorder. In Principles of Bone Biology (pp. 1463-1487). Elsevier.