Renal Osteodystrophy or Kidney-Induced Osteoporosis?

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Purpose of Review: Chronic kidney disease (CKD) affects nearly 10% of the population. The incidence of fractures in population studies demonstrate an increase with worsening stages of kidney disease suggesting specific CKD related causes of fracture. Recent Findings: The increase in fractures with CKD most likely represents disordered bone quality due to the abnormal bone remodeling from renal osteodystrophy. There is also an increase in fractures with age in patients with CKD, suggesting that patients with CKD also have many fracture risk factors common to patients without known CKD. Osteoporosis is defined by the National Institutes of Health as “A skeletal disorder characterized by compromised bone strength predisposing to an increased risk of fracture. Bone strength reflects the integration of two main features: bone quantity and bone quality.” Summary: Thus, CKD-related fractures can be considered a type of osteoporosis—where the bone quality is additionally impaired above that of age/hormonal-related osteoporosis. Perhaps using the term CKD-induced osteoporosis, similar to steroid-induced osteoporosis, will allow patients with CKD to be studied in trials investigating therapeutic agents. In this series, we will examine how CKD-induced osteoporosis may be diagnosed and treated.

Original languageEnglish (US)
Pages (from-to)1-4
Number of pages4
JournalCurrent Osteoporosis Reports
DOIs
StateAccepted/In press - May 11 2017

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Chronic Kidney Disease-Mineral and Bone Disorder
Chronic Renal Insufficiency
Osteoporosis
Kidney
Bone and Bones
Bone Remodeling
National Institutes of Health (U.S.)
Kidney Diseases
Population
Steroids

Keywords

  • CKD
  • Osteoporosis
  • Renal osteodystrophy

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Renal Osteodystrophy or Kidney-Induced Osteoporosis? / Moe, Sharon.

In: Current Osteoporosis Reports, 11.05.2017, p. 1-4.

Research output: Contribution to journalArticle

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