Renal response to ringer expansion in developing rats

B. S. Misanko, A. P. Evan, H. H. Bengele, Sidney Solomon

Research output: Contribution to journalArticle

10 Scopus citations


Male rats were studied between 20 and 60 days of age. Standard renal clearance techniques were used. The efficiency of the diuretic response, the sodium response, and the potassium response were calculated as defined previously. Results indicate that both diuretic and sodium efficiency is lower between the ages of 20 and 30 days as compared to 40 and 60 days of age, whereas potassium efficiency shows no age deoendence. In morphological studies, it has been observed that the proximal tubule cells of 22-day-old rats show changes in lateral intercellular spaces with comparable features to those of mature animals. The spaces widened during volume expansion. The change is quantitatively the same as that found in mature rats. Both blood pressure and hematocrit show continuous increase with age. The response of Ringer infusion in both immature and mature animals may be a mixed response involving changes in physical factors and renal responses to volume expansion per se.

Original languageEnglish (US)
Pages (from-to)52-59
Number of pages8
Issue number1-2
StatePublished - Jan 1 1979
Externally publishedYes


  • Blood pressure
  • Development
  • Glomerular filtration rate
  • Kidney
  • Lateral intercellular space
  • Morphology
  • Potassium
  • Sodium
  • Volume regulation
  • Water excretion

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology

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  • Cite this

    Misanko, B. S., Evan, A. P., Bengele, H. H., & Solomon, S. (1979). Renal response to ringer expansion in developing rats. Neonatology, 35(1-2), 52-59.