Repeated Chlamydia trachomatis genital infections in adolescent women

Byron E. Batteiger, Wanzhu Tu, Susan Ofner, Barbara Van Der Pol, Diane R. Stothard, Donald P. Orr, Barry P. Katz, J. Dennis Fortenberry

Research output: Contribution to journalArticle

179 Citations (Scopus)

Abstract

Background. Repeated Chlamydia trachomatis infections are common among young sexually active women. The relative frequency of reinfection and antibiotic treatment failure is undefined. Methods. Adolescent women enrolled in a longitudinal cohort had behavioral and sexually transmitted infection assessments performed every 3 months, including amplification tests for C. trachomatis, ompA genotyping, and interviews and diary entries to document sex partner-specific coitus and event-specific condom use. Repeated infections were classified as reinfection or treatment failure by use of an algorithm. All infections for which treatment outcomes were known were used to estimate the effectiveness of antibiotic use. Results. We observed 478 episodes of infection among 210 study participants; 176 women remained uninfected. The incidence rate was 34 episodes/100 woman-years. Of the women who were infected, 121 experienced ≥ 1 repeated infections, forming 268 episode pairs; 183 pairs had complete data available and were classified using the algorithm. Of the repeated infections, 84.2% were definite, probable, or possible reinfections; 13.7% were probable or possible treatment failures; and 2.2% persisted without documented treatment. For 318 évaluable infections, we estimated 92.2% effectiveness of antibiotic use. Conclusions. Most repeated chlamydial infections in this high-incidence cohort were reinfections, but repeated infections resulting from treatment failures occurred as well. Our results have implications for male screening and partner notification programs and suggest the need for improved antibiotic therapies.

Original languageEnglish (US)
Pages (from-to)42-51
Number of pages10
JournalJournal of Infectious Diseases
Volume201
Issue number1
DOIs
StatePublished - Jan 1 2010

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Chlamydia trachomatis
Infection
Treatment Failure
Anti-Bacterial Agents
Contact Tracing
Chlamydia Infections
Coitus
Incidence
Condoms
Sexually Transmitted Diseases
Interviews
Therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Repeated Chlamydia trachomatis genital infections in adolescent women. / Batteiger, Byron E.; Tu, Wanzhu; Ofner, Susan; Van Der Pol, Barbara; Stothard, Diane R.; Orr, Donald P.; Katz, Barry P.; Fortenberry, J. Dennis.

In: Journal of Infectious Diseases, Vol. 201, No. 1, 01.01.2010, p. 42-51.

Research output: Contribution to journalArticle

Batteiger, Byron E. ; Tu, Wanzhu ; Ofner, Susan ; Van Der Pol, Barbara ; Stothard, Diane R. ; Orr, Donald P. ; Katz, Barry P. ; Fortenberry, J. Dennis. / Repeated Chlamydia trachomatis genital infections in adolescent women. In: Journal of Infectious Diseases. 2010 ; Vol. 201, No. 1. pp. 42-51.
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