Replication-competent retroviruses in gene-modified T cells used in clinical trials: Is it time to revise the testing requirements?

Adham S. Bear, Richard A. Morgan, Kenneth Cornetta, Carl H. June, Gwendolyn Binder-Scholl, Mark E. Dudley, Steven A. Feldman, Steven A. Rosenberg, Sheila A. Shurtleff, Cliona M. Rooney, Helen E. Heslop, Gianpietro Dotti

Research output: Contribution to journalComment/debate

36 Citations (Scopus)
Original languageEnglish (US)
Pages (from-to)246-249
Number of pages4
JournalMolecular Therapy
Volume20
Issue number2
DOIs
StatePublished - Feb 1 2012

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Genetic Transduction
Toxicity Tests
Genetic Vectors
Retroviridae
Virus Replication
Genetic Therapy
Clinical Trials
T-Lymphocytes
Cell Line
Genes

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pharmacology
  • Drug Discovery

Cite this

Replication-competent retroviruses in gene-modified T cells used in clinical trials : Is it time to revise the testing requirements? / Bear, Adham S.; Morgan, Richard A.; Cornetta, Kenneth; June, Carl H.; Binder-Scholl, Gwendolyn; Dudley, Mark E.; Feldman, Steven A.; Rosenberg, Steven A.; Shurtleff, Sheila A.; Rooney, Cliona M.; Heslop, Helen E.; Dotti, Gianpietro.

In: Molecular Therapy, Vol. 20, No. 2, 01.02.2012, p. 246-249.

Research output: Contribution to journalComment/debate

Bear, AS, Morgan, RA, Cornetta, K, June, CH, Binder-Scholl, G, Dudley, ME, Feldman, SA, Rosenberg, SA, Shurtleff, SA, Rooney, CM, Heslop, HE & Dotti, G 2012, 'Replication-competent retroviruses in gene-modified T cells used in clinical trials: Is it time to revise the testing requirements?', Molecular Therapy, vol. 20, no. 2, pp. 246-249. https://doi.org/10.1038/mt.2011.288
Bear, Adham S. ; Morgan, Richard A. ; Cornetta, Kenneth ; June, Carl H. ; Binder-Scholl, Gwendolyn ; Dudley, Mark E. ; Feldman, Steven A. ; Rosenberg, Steven A. ; Shurtleff, Sheila A. ; Rooney, Cliona M. ; Heslop, Helen E. ; Dotti, Gianpietro. / Replication-competent retroviruses in gene-modified T cells used in clinical trials : Is it time to revise the testing requirements?. In: Molecular Therapy. 2012 ; Vol. 20, No. 2. pp. 246-249.
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