Report of selective cortical infarcts in the primate clot model of vasospasm after subarachnoid hemorrhage

Bawarjan Schatlo, Jens P. Dreier, Sven Gläsker, Ali Reza Fathi, Travis Moncrief, Edward H. Oldfield, Alexander Vortmeyer, Ryszard M. Pluta

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: In human autopsy studies, 70% to 80% of patients with aneurysmal subarachnoid hemorrhage (SAH) showed infarcts in cerebral cortex covered by subarachnoid blood. Thus far, no animal model of SAH is known to produce this peculiar infarct pattern, and its pathogenesis remains enigmatic. Objective: To investigate whether such infarcts occur in the clot model of SAH in primates. Methods: We performed a retrospective pathological review of 16 primate brains. In 13 cynomolgus monkeys, a blood clot was placed around the middle cerebral artery after additional removal of the arachnoid membrane from the basal surface of the frontal and temporal cortexes. Three animals underwent sham surgery without placement of a blood clot (controls). The brains were harvested between days 1 and 28 after SAH and examined by a neuropathologist blinded to study group. Results: We identified 2 types of cortical infarcts. A band of selective cortical laminar necrosis parallel to the cortical surface ("horizontal") was found in 5 animals. The second category of cortical lesions had a "vertical" extension. It included wedge-shaped (n = 2) or pillarlike (n = 2) necrosis. Both horizontal and vertical infarcts were located exclusively in areas adjacent to subarachnoid blood. The presence of a cortical infarct did not correlate with the degree of middle cerebral artery vasospasm (r =.24, P =.13). Conclusion: The presence of cortical infarcts suggests that a modified nonhuman primate model of SAH is suitable to examine the pathogenesis of proximal vasospasm and permits investigation of cortical lesions similar to those reported in patients after SAH. Furthermore, it indicates that direct effects of the blood clot on the brain and microcirculation contribute to the development of cortical infarcts after SAH.

Original languageEnglish (US)
Pages (from-to)721-728
Number of pages8
JournalNeurosurgery
Volume67
Issue number3
DOIs
StatePublished - Sep 1 2010
Externally publishedYes

Fingerprint

Subarachnoid Hemorrhage
Primates
Thrombosis
Middle Cerebral Artery
Brain
Necrosis
Arachnoid
Intracranial Vasospasm
Macaca fascicularis
Frontal Lobe
Temporal Lobe
Microcirculation
Cerebral Cortex
Autopsy
Animal Models
Membranes

Keywords

  • Cortical laminar necrosis
  • Cortical spreading ischemia
  • Delayed neurological deficit
  • Subarachnoid hemorrhage
  • Vasospasm

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Schatlo, B., Dreier, J. P., Gläsker, S., Fathi, A. R., Moncrief, T., Oldfield, E. H., ... Pluta, R. M. (2010). Report of selective cortical infarcts in the primate clot model of vasospasm after subarachnoid hemorrhage. Neurosurgery, 67(3), 721-728. https://doi.org/10.1227/01.NEU.0000378024.70848.8F

Report of selective cortical infarcts in the primate clot model of vasospasm after subarachnoid hemorrhage. / Schatlo, Bawarjan; Dreier, Jens P.; Gläsker, Sven; Fathi, Ali Reza; Moncrief, Travis; Oldfield, Edward H.; Vortmeyer, Alexander; Pluta, Ryszard M.

In: Neurosurgery, Vol. 67, No. 3, 01.09.2010, p. 721-728.

Research output: Contribution to journalArticle

Schatlo, B, Dreier, JP, Gläsker, S, Fathi, AR, Moncrief, T, Oldfield, EH, Vortmeyer, A & Pluta, RM 2010, 'Report of selective cortical infarcts in the primate clot model of vasospasm after subarachnoid hemorrhage', Neurosurgery, vol. 67, no. 3, pp. 721-728. https://doi.org/10.1227/01.NEU.0000378024.70848.8F
Schatlo, Bawarjan ; Dreier, Jens P. ; Gläsker, Sven ; Fathi, Ali Reza ; Moncrief, Travis ; Oldfield, Edward H. ; Vortmeyer, Alexander ; Pluta, Ryszard M. / Report of selective cortical infarcts in the primate clot model of vasospasm after subarachnoid hemorrhage. In: Neurosurgery. 2010 ; Vol. 67, No. 3. pp. 721-728.
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AU - Schatlo, Bawarjan

AU - Dreier, Jens P.

AU - Gläsker, Sven

AU - Fathi, Ali Reza

AU - Moncrief, Travis

AU - Oldfield, Edward H.

AU - Vortmeyer, Alexander

AU - Pluta, Ryszard M.

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