Reprint of: Stromogenic prostatic carcinoma pattern (carcinomas with reactive stromal grade 3) in needle biopsies predicts biochemical recurrence-free survival in patients after radical prostatectomy

Nobuyuki Yanagisawa, Rile Li, David Rowley, Hao Liu, Dov Kadmon, Brian J. Miles, Thomas M. Wheeler, Gustavo E. Ayala

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We previously reported that reactive stromal grading in radical prostatectomies is a predictor of recurrence and that reactive stromal grading 0 and 3 are associated with lower biochemical recurrence-free survival rates than reactive stromal grading 1 and 2. We explored the prognostic significance of reactive stromal grading in preoperative needle biopsies. At Baylor College of Medicine, 224 cases of prostatic carcinoma were diagnosed by needle biopsy. Reactive stromal grading was evaluated on hematoxylin-eosin (H&E)-stained sections on the basis of previously described criteria: grade 0, with 0% to 5% reactive stroma; grade 1, 6% to 15%; grade 2, 16% to 50%; grade 3, 51% to 100%, or at least a 1:1 ratio between glands and stroma. Kaplan-Meier and Cox proportional hazard analyses were used. Reactive stromal grading distribution was as follows: reactive stromal grading 0, 1 case (0.5%); reactive stromal grading 1, 149 cases (66.5%); reactive stromal grading 2, 59 cases (26.3%); reactive stromal grading 3, 15 cases (6.7%). Reactive stromal grading in biopsies was correlated with adverse clinicopathologic parameters in the prostatectomy. Patients with reactive stromal grading 1 and 2 had better survival than those with 0 and 3 (P = .0034). Reactive stromal grading was an independent predictor of recurrence (hazard ratio = 1.953; P = .0174). Reactive stromal grading is independent of Gleason 4 + 3 and 3 + 4 in patients with a Gleason score of 7. Quantitation of reactive stroma and recognition of the stromogenic carcinoma in H&E-stained biopsies is useful to predict biochemical recurrence in prostate carcinoma patients independent of Gleason grade and prostate-specific antigen.

Original languageEnglish (US)
Pages (from-to)282-291
Number of pages10
JournalHuman pathology
Volume39
Issue number2
DOIs
StatePublished - Feb 1 2008
Externally publishedYes

Fingerprint

Needle Biopsy
Prostatectomy
Carcinoma
Recurrence
Survival
Biopsy
Neoplasm Grading
Hematoxylin
Eosine Yellowish-(YS)
Prostate-Specific Antigen
Prostate
Survival Rate
Medicine

Keywords

  • Hematoxylin-eosin stain
  • Needle biopsy
  • Prognosis
  • Prostate cancer
  • Reactive stroma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Reprint of : Stromogenic prostatic carcinoma pattern (carcinomas with reactive stromal grade 3) in needle biopsies predicts biochemical recurrence-free survival in patients after radical prostatectomy. / Yanagisawa, Nobuyuki; Li, Rile; Rowley, David; Liu, Hao; Kadmon, Dov; Miles, Brian J.; Wheeler, Thomas M.; Ayala, Gustavo E.

In: Human pathology, Vol. 39, No. 2, 01.02.2008, p. 282-291.

Research output: Contribution to journalArticle

Yanagisawa, Nobuyuki ; Li, Rile ; Rowley, David ; Liu, Hao ; Kadmon, Dov ; Miles, Brian J. ; Wheeler, Thomas M. ; Ayala, Gustavo E. / Reprint of : Stromogenic prostatic carcinoma pattern (carcinomas with reactive stromal grade 3) in needle biopsies predicts biochemical recurrence-free survival in patients after radical prostatectomy. In: Human pathology. 2008 ; Vol. 39, No. 2. pp. 282-291.
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