Reproducibility assessment of brain responses to visual food stimuli in adults with overweight and obesity

R. Drew Sayer, Gregory G. Tamer, Ningning Chen, Jason R. Tregellas, Marc Andre Cornier, David Kareken, Thomas M. Talavage, Megan A. McCrory, Wayne W. Campbell

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: The brain's reward system influences ingestive behavior and subsequently obesity risk. Functional magnetic resonance imaging (fMRI) is a common method for investigating brain reward function. This study sought to assess the reproducibility of fasting-state brain responses to visual food stimuli using BOLD fMRI. Methods: A priori brain regions of interest included bilateral insula, amygdala, orbitofrontal cortex, caudate, and putamen. Fasting-state fMRI and appetite assessments were completed by 28 women (n = 16) and men (n = 12) with overweight or obesity on 2 days. Reproducibility was assessed by comparing mean fasting-state brain responses and measuring test-retest reliability of these responses on the two testing days. Results: Mean fasting-state brain responses on day 2 were reduced compared with day 1 in the left insula and right amygdala, but mean day 1 and day 2 responses were not different in the other regions of interest. With the exception of the left orbitofrontal cortex response (fair reliability), test-retest reliabilities of brain responses were poor or unreliable. Conclusions: fMRI-measured responses to visual food cues in adults with overweight or obesity show relatively good mean-level reproducibility but considerable within-subject variability. Poor test-retest reliability reduces the likelihood of observing true correlations and increases the necessary sample sizes for studies.

Original languageEnglish (US)
Pages (from-to)2057-2063
Number of pages7
JournalObesity
Volume24
Issue number10
DOIs
StatePublished - Oct 1 2016

Fingerprint

Obesity
Food
Brain
Fasting
Magnetic Resonance Imaging
Reproducibility of Results
Amygdala
Prefrontal Cortex
Reward
Putamen
Appetite
Sample Size
Cues

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Drew Sayer, R., Tamer, G. G., Chen, N., Tregellas, J. R., Cornier, M. A., Kareken, D., ... Campbell, W. W. (2016). Reproducibility assessment of brain responses to visual food stimuli in adults with overweight and obesity. Obesity, 24(10), 2057-2063. https://doi.org/10.1002/oby.21603

Reproducibility assessment of brain responses to visual food stimuli in adults with overweight and obesity. / Drew Sayer, R.; Tamer, Gregory G.; Chen, Ningning; Tregellas, Jason R.; Cornier, Marc Andre; Kareken, David; Talavage, Thomas M.; McCrory, Megan A.; Campbell, Wayne W.

In: Obesity, Vol. 24, No. 10, 01.10.2016, p. 2057-2063.

Research output: Contribution to journalArticle

Drew Sayer, R, Tamer, GG, Chen, N, Tregellas, JR, Cornier, MA, Kareken, D, Talavage, TM, McCrory, MA & Campbell, WW 2016, 'Reproducibility assessment of brain responses to visual food stimuli in adults with overweight and obesity', Obesity, vol. 24, no. 10, pp. 2057-2063. https://doi.org/10.1002/oby.21603
Drew Sayer, R. ; Tamer, Gregory G. ; Chen, Ningning ; Tregellas, Jason R. ; Cornier, Marc Andre ; Kareken, David ; Talavage, Thomas M. ; McCrory, Megan A. ; Campbell, Wayne W. / Reproducibility assessment of brain responses to visual food stimuli in adults with overweight and obesity. In: Obesity. 2016 ; Vol. 24, No. 10. pp. 2057-2063.
@article{88edab8b082a44e4a5b5e178c68bc1d1,
title = "Reproducibility assessment of brain responses to visual food stimuli in adults with overweight and obesity",
abstract = "Objective: The brain's reward system influences ingestive behavior and subsequently obesity risk. Functional magnetic resonance imaging (fMRI) is a common method for investigating brain reward function. This study sought to assess the reproducibility of fasting-state brain responses to visual food stimuli using BOLD fMRI. Methods: A priori brain regions of interest included bilateral insula, amygdala, orbitofrontal cortex, caudate, and putamen. Fasting-state fMRI and appetite assessments were completed by 28 women (n = 16) and men (n = 12) with overweight or obesity on 2 days. Reproducibility was assessed by comparing mean fasting-state brain responses and measuring test-retest reliability of these responses on the two testing days. Results: Mean fasting-state brain responses on day 2 were reduced compared with day 1 in the left insula and right amygdala, but mean day 1 and day 2 responses were not different in the other regions of interest. With the exception of the left orbitofrontal cortex response (fair reliability), test-retest reliabilities of brain responses were poor or unreliable. Conclusions: fMRI-measured responses to visual food cues in adults with overweight or obesity show relatively good mean-level reproducibility but considerable within-subject variability. Poor test-retest reliability reduces the likelihood of observing true correlations and increases the necessary sample sizes for studies.",
author = "{Drew Sayer}, R. and Tamer, {Gregory G.} and Ningning Chen and Tregellas, {Jason R.} and Cornier, {Marc Andre} and David Kareken and Talavage, {Thomas M.} and McCrory, {Megan A.} and Campbell, {Wayne W.}",
year = "2016",
month = "10",
day = "1",
doi = "10.1002/oby.21603",
language = "English (US)",
volume = "24",
pages = "2057--2063",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
number = "10",

}

TY - JOUR

T1 - Reproducibility assessment of brain responses to visual food stimuli in adults with overweight and obesity

AU - Drew Sayer, R.

AU - Tamer, Gregory G.

AU - Chen, Ningning

AU - Tregellas, Jason R.

AU - Cornier, Marc Andre

AU - Kareken, David

AU - Talavage, Thomas M.

AU - McCrory, Megan A.

AU - Campbell, Wayne W.

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Objective: The brain's reward system influences ingestive behavior and subsequently obesity risk. Functional magnetic resonance imaging (fMRI) is a common method for investigating brain reward function. This study sought to assess the reproducibility of fasting-state brain responses to visual food stimuli using BOLD fMRI. Methods: A priori brain regions of interest included bilateral insula, amygdala, orbitofrontal cortex, caudate, and putamen. Fasting-state fMRI and appetite assessments were completed by 28 women (n = 16) and men (n = 12) with overweight or obesity on 2 days. Reproducibility was assessed by comparing mean fasting-state brain responses and measuring test-retest reliability of these responses on the two testing days. Results: Mean fasting-state brain responses on day 2 were reduced compared with day 1 in the left insula and right amygdala, but mean day 1 and day 2 responses were not different in the other regions of interest. With the exception of the left orbitofrontal cortex response (fair reliability), test-retest reliabilities of brain responses were poor or unreliable. Conclusions: fMRI-measured responses to visual food cues in adults with overweight or obesity show relatively good mean-level reproducibility but considerable within-subject variability. Poor test-retest reliability reduces the likelihood of observing true correlations and increases the necessary sample sizes for studies.

AB - Objective: The brain's reward system influences ingestive behavior and subsequently obesity risk. Functional magnetic resonance imaging (fMRI) is a common method for investigating brain reward function. This study sought to assess the reproducibility of fasting-state brain responses to visual food stimuli using BOLD fMRI. Methods: A priori brain regions of interest included bilateral insula, amygdala, orbitofrontal cortex, caudate, and putamen. Fasting-state fMRI and appetite assessments were completed by 28 women (n = 16) and men (n = 12) with overweight or obesity on 2 days. Reproducibility was assessed by comparing mean fasting-state brain responses and measuring test-retest reliability of these responses on the two testing days. Results: Mean fasting-state brain responses on day 2 were reduced compared with day 1 in the left insula and right amygdala, but mean day 1 and day 2 responses were not different in the other regions of interest. With the exception of the left orbitofrontal cortex response (fair reliability), test-retest reliabilities of brain responses were poor or unreliable. Conclusions: fMRI-measured responses to visual food cues in adults with overweight or obesity show relatively good mean-level reproducibility but considerable within-subject variability. Poor test-retest reliability reduces the likelihood of observing true correlations and increases the necessary sample sizes for studies.

UR - http://www.scopus.com/inward/record.url?scp=84988733909&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84988733909&partnerID=8YFLogxK

U2 - 10.1002/oby.21603

DO - 10.1002/oby.21603

M3 - Article

C2 - 27542906

AN - SCOPUS:84988733909

VL - 24

SP - 2057

EP - 2063

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 10

ER -