Reproductive cycle-associated mood symptoms in women with major depression and bipolar disorder

Jennifer L. Payne, Patricia S. Roy, Kathleen Murphy-Eberenz, Myrna M. Weismann, Karen L. Swartz, Melvin G. McInnis, Eva Nwulia, Francis M. Mondimore, Dean F. MacKinnon, Erin B. Miller, John Nurnberger, Douglas F. Levinson, J. Raymond DePaulo, James B. Potash

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Background: We sought to determine the prevalence of, and association between, reproductive cycle-associated mood symptoms in women with affective disorders. We hypothesized that symptoms would correlate with each other across a woman's reproductive life span in both major depression (MDD) and bipolar I disorder (BP). Methods: 2412 women with, MDD or BP were asked standardized questions about mood symptoms prior to menstruation, within a month of childbirth and during perimenopause. Lifetime rates for each of these symptom types were determined and an odds ratio was calculated correlating each of the types with the others. Results: Of 2524 women with mood disorders, 67.7% reported premenstrual symptoms. Of those at risk, 20.9% reported postpartum symptoms and 26.4% reported perimenopausal symptoms. The rates did not differ between women with MDD and BP but were significantly different from women who were never ill. The symptoms were significantly correlated in women with MDD with odds ratios from 1.66 to 1.82, but were not in women with BP. Limitations: This is a secondary analysis of a sample that was collected for other purposes and is based upon retrospecitve reporting. Conclusions: Reproductive cycle-associated mood symptoms were commonly reported in women with mood disorders and did not differ based on diagnosis. In MDD, but not BP, the occurrence of these symptoms was trait-like as the presence of one predicted the occurrence of the others. Further prospective study is required to clarify the determinants of this trait.

Original languageEnglish (US)
Pages (from-to)221-229
Number of pages9
JournalJournal of Affective Disorders
Volume99
Issue number1-3
DOIs
StatePublished - Apr 2007
Externally publishedYes

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Bipolar Disorder
Depression
Mood Disorders
Odds Ratio
Perimenopause
Menstruation
Postpartum Period
Parturition
Prospective Studies

Keywords

  • Bipolar disorder
  • Major depression
  • Perimenopausal
  • Postpartum
  • Premenstrual

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

Payne, J. L., Roy, P. S., Murphy-Eberenz, K., Weismann, M. M., Swartz, K. L., McInnis, M. G., ... Potash, J. B. (2007). Reproductive cycle-associated mood symptoms in women with major depression and bipolar disorder. Journal of Affective Disorders, 99(1-3), 221-229. https://doi.org/10.1016/j.jad.2006.08.013

Reproductive cycle-associated mood symptoms in women with major depression and bipolar disorder. / Payne, Jennifer L.; Roy, Patricia S.; Murphy-Eberenz, Kathleen; Weismann, Myrna M.; Swartz, Karen L.; McInnis, Melvin G.; Nwulia, Eva; Mondimore, Francis M.; MacKinnon, Dean F.; Miller, Erin B.; Nurnberger, John; Levinson, Douglas F.; DePaulo, J. Raymond; Potash, James B.

In: Journal of Affective Disorders, Vol. 99, No. 1-3, 04.2007, p. 221-229.

Research output: Contribution to journalArticle

Payne, JL, Roy, PS, Murphy-Eberenz, K, Weismann, MM, Swartz, KL, McInnis, MG, Nwulia, E, Mondimore, FM, MacKinnon, DF, Miller, EB, Nurnberger, J, Levinson, DF, DePaulo, JR & Potash, JB 2007, 'Reproductive cycle-associated mood symptoms in women with major depression and bipolar disorder', Journal of Affective Disorders, vol. 99, no. 1-3, pp. 221-229. https://doi.org/10.1016/j.jad.2006.08.013
Payne, Jennifer L. ; Roy, Patricia S. ; Murphy-Eberenz, Kathleen ; Weismann, Myrna M. ; Swartz, Karen L. ; McInnis, Melvin G. ; Nwulia, Eva ; Mondimore, Francis M. ; MacKinnon, Dean F. ; Miller, Erin B. ; Nurnberger, John ; Levinson, Douglas F. ; DePaulo, J. Raymond ; Potash, James B. / Reproductive cycle-associated mood symptoms in women with major depression and bipolar disorder. In: Journal of Affective Disorders. 2007 ; Vol. 99, No. 1-3. pp. 221-229.
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abstract = "Background: We sought to determine the prevalence of, and association between, reproductive cycle-associated mood symptoms in women with affective disorders. We hypothesized that symptoms would correlate with each other across a woman's reproductive life span in both major depression (MDD) and bipolar I disorder (BP). Methods: 2412 women with, MDD or BP were asked standardized questions about mood symptoms prior to menstruation, within a month of childbirth and during perimenopause. Lifetime rates for each of these symptom types were determined and an odds ratio was calculated correlating each of the types with the others. Results: Of 2524 women with mood disorders, 67.7{\%} reported premenstrual symptoms. Of those at risk, 20.9{\%} reported postpartum symptoms and 26.4{\%} reported perimenopausal symptoms. The rates did not differ between women with MDD and BP but were significantly different from women who were never ill. The symptoms were significantly correlated in women with MDD with odds ratios from 1.66 to 1.82, but were not in women with BP. Limitations: This is a secondary analysis of a sample that was collected for other purposes and is based upon retrospecitve reporting. Conclusions: Reproductive cycle-associated mood symptoms were commonly reported in women with mood disorders and did not differ based on diagnosis. In MDD, but not BP, the occurrence of these symptoms was trait-like as the presence of one predicted the occurrence of the others. Further prospective study is required to clarify the determinants of this trait.",
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AU - Payne, Jennifer L.

AU - Roy, Patricia S.

AU - Murphy-Eberenz, Kathleen

AU - Weismann, Myrna M.

AU - Swartz, Karen L.

AU - McInnis, Melvin G.

AU - Nwulia, Eva

AU - Mondimore, Francis M.

AU - MacKinnon, Dean F.

AU - Miller, Erin B.

AU - Nurnberger, John

AU - Levinson, Douglas F.

AU - DePaulo, J. Raymond

AU - Potash, James B.

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N2 - Background: We sought to determine the prevalence of, and association between, reproductive cycle-associated mood symptoms in women with affective disorders. We hypothesized that symptoms would correlate with each other across a woman's reproductive life span in both major depression (MDD) and bipolar I disorder (BP). Methods: 2412 women with, MDD or BP were asked standardized questions about mood symptoms prior to menstruation, within a month of childbirth and during perimenopause. Lifetime rates for each of these symptom types were determined and an odds ratio was calculated correlating each of the types with the others. Results: Of 2524 women with mood disorders, 67.7% reported premenstrual symptoms. Of those at risk, 20.9% reported postpartum symptoms and 26.4% reported perimenopausal symptoms. The rates did not differ between women with MDD and BP but were significantly different from women who were never ill. The symptoms were significantly correlated in women with MDD with odds ratios from 1.66 to 1.82, but were not in women with BP. Limitations: This is a secondary analysis of a sample that was collected for other purposes and is based upon retrospecitve reporting. Conclusions: Reproductive cycle-associated mood symptoms were commonly reported in women with mood disorders and did not differ based on diagnosis. In MDD, but not BP, the occurrence of these symptoms was trait-like as the presence of one predicted the occurrence of the others. Further prospective study is required to clarify the determinants of this trait.

AB - Background: We sought to determine the prevalence of, and association between, reproductive cycle-associated mood symptoms in women with affective disorders. We hypothesized that symptoms would correlate with each other across a woman's reproductive life span in both major depression (MDD) and bipolar I disorder (BP). Methods: 2412 women with, MDD or BP were asked standardized questions about mood symptoms prior to menstruation, within a month of childbirth and during perimenopause. Lifetime rates for each of these symptom types were determined and an odds ratio was calculated correlating each of the types with the others. Results: Of 2524 women with mood disorders, 67.7% reported premenstrual symptoms. Of those at risk, 20.9% reported postpartum symptoms and 26.4% reported perimenopausal symptoms. The rates did not differ between women with MDD and BP but were significantly different from women who were never ill. The symptoms were significantly correlated in women with MDD with odds ratios from 1.66 to 1.82, but were not in women with BP. Limitations: This is a secondary analysis of a sample that was collected for other purposes and is based upon retrospecitve reporting. Conclusions: Reproductive cycle-associated mood symptoms were commonly reported in women with mood disorders and did not differ based on diagnosis. In MDD, but not BP, the occurrence of these symptoms was trait-like as the presence of one predicted the occurrence of the others. Further prospective study is required to clarify the determinants of this trait.

KW - Bipolar disorder

KW - Major depression

KW - Perimenopausal

KW - Postpartum

KW - Premenstrual

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