Requirement for positive selection of γδ receptor-bearing T cells

Faith B. Wells, Sara Jo Gahm, Stephen M. Hedrick, Jeffrey A. Bluestone, Alexander Dent, Louis A. Matis

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

The αβ and γδ T cell receptors for antigen (TCR) delineate distinct T cell populations. TCRαβ-bearing thymocytes must be positively selected by binding of the TCR to major histocompatibility complex (MHC) molecules on thymic epithelium. To examine the reqiurements for positive selection of TCR γδ T cells, mice bearing a class I MHC-specific γδ transgene (Tg) were crossed to mice with disrupted β2 microglobulin (β2M) genes. The Tg+β2M- (class I MHC-) offspring had Tg+ thymocytes that did not proliferate to antigen or Tg-specific monoclonal antibody and few peripheral did not proliferate to antigen or Tg-specific monoclonal antibody and few peripheral Tg+ cells. This is evidence for positive selection within the γδ T cell subset.

Original languageEnglish (US)
Pages (from-to)903-905
Number of pages3
JournalScience
Volume253
Issue number5022
StatePublished - Aug 23 1991
Externally publishedYes

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T-Cell Antigen Receptor
Transgenes
Major Histocompatibility Complex
Thymocytes
Monoclonal Antibodies
T-Lymphocytes
Antigens
T-Lymphocyte Subsets
Epithelium
Population
Genes

ASJC Scopus subject areas

  • General

Cite this

Wells, F. B., Gahm, S. J., Hedrick, S. M., Bluestone, J. A., Dent, A., & Matis, L. A. (1991). Requirement for positive selection of γδ receptor-bearing T cells. Science, 253(5022), 903-905.

Requirement for positive selection of γδ receptor-bearing T cells. / Wells, Faith B.; Gahm, Sara Jo; Hedrick, Stephen M.; Bluestone, Jeffrey A.; Dent, Alexander; Matis, Louis A.

In: Science, Vol. 253, No. 5022, 23.08.1991, p. 903-905.

Research output: Contribution to journalArticle

Wells, FB, Gahm, SJ, Hedrick, SM, Bluestone, JA, Dent, A & Matis, LA 1991, 'Requirement for positive selection of γδ receptor-bearing T cells', Science, vol. 253, no. 5022, pp. 903-905.
Wells FB, Gahm SJ, Hedrick SM, Bluestone JA, Dent A, Matis LA. Requirement for positive selection of γδ receptor-bearing T cells. Science. 1991 Aug 23;253(5022):903-905.
Wells, Faith B. ; Gahm, Sara Jo ; Hedrick, Stephen M. ; Bluestone, Jeffrey A. ; Dent, Alexander ; Matis, Louis A. / Requirement for positive selection of γδ receptor-bearing T cells. In: Science. 1991 ; Vol. 253, No. 5022. pp. 903-905.
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