Requirement for positive selection of γδ receptor-bearing T cells

Faith B. Wells, Sara Jo Gahm, Stephen M. Hedrick, Jeffrey A. Bluestone, Alexander Dent, Louis A. Matis

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62 Scopus citations

Abstract

The αβ and γδ T cell receptors for antigen (TCR) delineate distinct T cell populations. TCRαβ-bearing thymocytes must be positively selected by binding of the TCR to major histocompatibility complex (MHC) molecules on thymic epithelium. To examine the reqiurements for positive selection of TCR γδ T cells, mice bearing a class I MHC-specific γδ transgene (Tg) were crossed to mice with disrupted β2 microglobulin (β2M) genes. The Tg+β2M- (class I MHC-) offspring had Tg+ thymocytes that did not proliferate to antigen or Tg-specific monoclonal antibody and few peripheral did not proliferate to antigen or Tg-specific monoclonal antibody and few peripheral Tg+ cells. This is evidence for positive selection within the γδ T cell subset.

Original languageEnglish (US)
Pages (from-to)903-905
Number of pages3
JournalScience
Volume253
Issue number5022
DOIs
StatePublished - Aug 23 1991
Externally publishedYes

ASJC Scopus subject areas

  • General

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    Wells, F. B., Gahm, S. J., Hedrick, S. M., Bluestone, J. A., Dent, A., & Matis, L. A. (1991). Requirement for positive selection of γδ receptor-bearing T cells. Science, 253(5022), 903-905. https://doi.org/10.1126/science.1831565