Research advances in apoptosis-mediated cancer therapy

A review

Antonio Lopez-Beltran, Gregory T. MacLennan, Juan De La Haba-Rodriguez, Rodolfo Montironi, Liang Cheng

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Apoptosis (programmed cell death) research has received much attention because of its wide-ranging implications in tissue kinetics. The ability of malignant cells to evade apoptosis is a hallmark of cancer, and their resistance to apoptosis constitutes an important clinical problem. Targeting proteins from the apoptotic signaling pathways for cancer therapy is currently an important research strategy, with some compounds entering clinical trials as novel therapeutic drugs in cancer medicine. These compounds may target the apoptosis machinery or may be inhibitors of growth factors that kill tumor cells via apoptosis. This review summarizes current observations in the literature related to recent research developments in apoptosis-mediated cancer therapy.

Original languageEnglish
Pages (from-to)71-78
Number of pages8
JournalAnalytical and Quantitative Cytology and Histology
Volume29
Issue number2
StatePublished - Apr 2007

Fingerprint

Apoptosis
Research
Neoplasms
Therapeutics
Protein Transport
Intercellular Signaling Peptides and Proteins
Cell Death
Medicine
Clinical Trials
Pharmaceutical Preparations

Keywords

  • Apoptosis
  • Cancer
  • Therapy

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Cell Biology

Cite this

Lopez-Beltran, A., MacLennan, G. T., De La Haba-Rodriguez, J., Montironi, R., & Cheng, L. (2007). Research advances in apoptosis-mediated cancer therapy: A review. Analytical and Quantitative Cytology and Histology, 29(2), 71-78.

Research advances in apoptosis-mediated cancer therapy : A review. / Lopez-Beltran, Antonio; MacLennan, Gregory T.; De La Haba-Rodriguez, Juan; Montironi, Rodolfo; Cheng, Liang.

In: Analytical and Quantitative Cytology and Histology, Vol. 29, No. 2, 04.2007, p. 71-78.

Research output: Contribution to journalArticle

Lopez-Beltran, A, MacLennan, GT, De La Haba-Rodriguez, J, Montironi, R & Cheng, L 2007, 'Research advances in apoptosis-mediated cancer therapy: A review', Analytical and Quantitative Cytology and Histology, vol. 29, no. 2, pp. 71-78.
Lopez-Beltran A, MacLennan GT, De La Haba-Rodriguez J, Montironi R, Cheng L. Research advances in apoptosis-mediated cancer therapy: A review. Analytical and Quantitative Cytology and Histology. 2007 Apr;29(2):71-78.
Lopez-Beltran, Antonio ; MacLennan, Gregory T. ; De La Haba-Rodriguez, Juan ; Montironi, Rodolfo ; Cheng, Liang. / Research advances in apoptosis-mediated cancer therapy : A review. In: Analytical and Quantitative Cytology and Histology. 2007 ; Vol. 29, No. 2. pp. 71-78.
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