Resistance to systemic agents in renal cell carcinoma predict and overcome genomic strategies adopted by tumor

Veronica Mollica, Vincenzo Di Nunno, Lidia Gatto, Matteo Santoni, Marina Scarpelli, Alessia Cimadamore, Antonio Lopez-Beltran, Liang Cheng, Nicola Battelli, Rodolfo Montironi, Francesco Massari

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

The development of new systemic agents has led us into a “golden era” of management of metastatic renal cell carcinoma (RCC). Certainly, the approval of immune-checkpoint inhibitors and the combination of these with targeted compounds has irreversibly changed clinical scenarios. A deeper knowledge of the molecular mechanisms that correlate with tumor development and progression has made this revolution possible. In this amazing era, novel challenges are awaiting us in the clinical management of metastatic RCC. Of these, the development of reliable criteria which are able to predict tumor response to treatment or primary and acquired resistance to systemic treatments still remain an unmet clinical need. Thanks to the availability of data provided by studies evaluating genomic assessments of the disease, this goal may no longer be out of reach. In this review, we summarize current knowledge about genomic alterations related to primary and secondary resistance to target therapy and immune-checkpoint inhibitors in RCC.

Original languageEnglish (US)
Article number830
JournalCancers
Volume11
Issue number6
DOIs
StatePublished - Jun 2019

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Keywords

  • Acquired resistance
  • Immune-checkpoint inhibitors
  • PD-1/PD-L1
  • Predictive markers
  • Primary resistance
  • Renal cell carcinoma
  • Target therapy
  • VEGF
  • VEGFR
  • mTOR

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Mollica, V., Di Nunno, V., Gatto, L., Santoni, M., Scarpelli, M., Cimadamore, A., Lopez-Beltran, A., Cheng, L., Battelli, N., Montironi, R., & Massari, F. (2019). Resistance to systemic agents in renal cell carcinoma predict and overcome genomic strategies adopted by tumor. Cancers, 11(6), [830]. https://doi.org/10.3390/cancers11060830