Respiratory consequences of prematurity: Evolution of a diagnosis and development of a comprehensive approach

N. L. Maitre, R. A. Ballard, J. H. Ellenberg, Stephanie Davis, J. M. Greenberg, A. Hamvas, G. S. Pryhuber

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Bronchopulmonary dysplasia (BPD) is the most common respiratory consequence of premature birth and contributes to significant short- and long-term morbidity, mortality and resource utilization. Initially defined as a radiographic, clinical and histopathological entity, the chronic lung disease known as BPD has evolved as obstetrical and neonatal care have improved the survival of lower gestational age infants. Now, definitions based on the need for supplementary oxygen at 28 days and/or 36 weeks provide a useful reference point in the neonatal intensive-care unit (NICU), but are no longer based on histopathological findings, and are neither designed to predict longer term respiratory consequences nor to study the evolution of a multifactorial disease. The aims of this review are to critically examine the evolution of the diagnosis of BPD and the challenges inherent to current classifications. We found that the increasing use of respiratory support strategies that administer ambient air without supplementary oxygen confounds oxygen-based definitions of BPD. Furthermore, lack of reproducible, genetic, biochemical and physiological biomarkers limits the ability to identify an impending BPD for early intervention, quantify disease severity for standardized classification and approaches and reliably predict the long-term outcomes. More comprehensive, multidisciplinary approaches to overcome these challenges involve longitudinal observation of extremely preterm infants, not only those with BPD, using genetic, environmental, physiological and clinical data as well as large databases of patient samples. The Prematurity and Respiratory Outcomes Program (PROP) will provide such a framework to address these challenges through high-resolution characterization of both NICU and post-NICU discharge outcomes.

Original languageEnglish (US)
Pages (from-to)313-321
Number of pages9
JournalJournal of Perinatology
Volume35
Issue number5
DOIs
StatePublished - May 30 2015

Fingerprint

Bronchopulmonary Dysplasia
Neonatal Intensive Care Units
Oxygen
Extremely Premature Infants
Premature Birth
Lung Diseases
Gestational Age
Molecular Biology
Chronic Disease
Biomarkers
Air
Observation
Databases
Morbidity
Survival
Mortality

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Maitre, N. L., Ballard, R. A., Ellenberg, J. H., Davis, S., Greenberg, J. M., Hamvas, A., & Pryhuber, G. S. (2015). Respiratory consequences of prematurity: Evolution of a diagnosis and development of a comprehensive approach. Journal of Perinatology, 35(5), 313-321. https://doi.org/10.1038/jp.2015.19

Respiratory consequences of prematurity : Evolution of a diagnosis and development of a comprehensive approach. / Maitre, N. L.; Ballard, R. A.; Ellenberg, J. H.; Davis, Stephanie; Greenberg, J. M.; Hamvas, A.; Pryhuber, G. S.

In: Journal of Perinatology, Vol. 35, No. 5, 30.05.2015, p. 313-321.

Research output: Contribution to journalArticle

Maitre, NL, Ballard, RA, Ellenberg, JH, Davis, S, Greenberg, JM, Hamvas, A & Pryhuber, GS 2015, 'Respiratory consequences of prematurity: Evolution of a diagnosis and development of a comprehensive approach', Journal of Perinatology, vol. 35, no. 5, pp. 313-321. https://doi.org/10.1038/jp.2015.19
Maitre, N. L. ; Ballard, R. A. ; Ellenberg, J. H. ; Davis, Stephanie ; Greenberg, J. M. ; Hamvas, A. ; Pryhuber, G. S. / Respiratory consequences of prematurity : Evolution of a diagnosis and development of a comprehensive approach. In: Journal of Perinatology. 2015 ; Vol. 35, No. 5. pp. 313-321.
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