Response of non-Hodgkin lymphoma to radiation therapy: Early and long- term assessment with H-1 MR spectroscopic imaging

A. Bizzi, B. Movsas, G. Tedeschi, C. L. Phillips, P. Okunieff, J. R. Alger, G. Di Chiro

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

PURPOSE: To determine whether proton magnetic resonance (MR) spectroscopic imaging is a sensitive technique for defining tumor extent and assessing response of cerebral lymphoma to therapy. MATERIALS AND METHODS: Four hydrogen-1 MR spectroscopic imaging studies were performed in a patient with non-Hodgkin lymphoma (NHL) before, during, and after radiation therapy and at follow-up at 33 months after diagnosis of the recurrence of disease. The patient had a single, large lesion in the brain and underwent hyperfractionated radiation therapy for 4 weeks. A series of MR images was also obtained. RESULTS: The pretreatment study showed a lesion with a distinct spectral pattern: marked elevation of choline and lipids and great reduction of creatine and N-acetylaspartate. During and after treatment, H-1 MR spectroscopic images depicted a progressive reduction of the abnormal choline and lipid signals. Thirty-three months after treatment, multiple- section H-1 MR spectroscopic images showed normal spectral patterns in all sections examined. CONCLUSION: H-1 MR spectroscopy may contribute to the neuroradiologic evaluation of NHL and, in particular, may be useful in monitoring therapeutic response.

Original languageEnglish (US)
Pages (from-to)271-276
Number of pages6
JournalRadiology
Volume194
Issue number1
DOIs
StatePublished - Jan 1 1995
Externally publishedYes

Keywords

  • Brain neoplasms, emission CT
  • Brain neoplasms, secondary
  • Hodgkin disease, therapeutic radiology
  • Magnetic resonance (MR), spectroscopy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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