Response of warts in epidermodysplasia verruciformis to treatment with systemic and intralesional alpha interferon

Elliot J. Androphy, Israel Dvoretzky, Annette E. Maluish, H. James Wallace, Douglas R. Lowy

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

The susceptibility of human papillomavirus infection to polyclonal human leukocyte interferon (IFN-α) has been evaluated in patients with epidermodysplasia verruciformis (EV), a disease with extensive chronic papillomavirus-induced warts. In a double-blind, placebo-controlled study with intralesional IFN-α, four of five IFN-α-treated warts regressed; none of the placebo-treated warts responded (p = 0.024). Three patients with EV were treated with systemic IFN-α for 4 weeks in an open study, achieving partial regression of warts in all three. In a double-blind, placebo-controlled study, warts in two children with EV regressed with systemic IFN-α while two who received placebo showed no improvement. The lesions recurred following cessation of Therapy. At the completion of therapy with IFN-α, histologic normalization was accompanied by a 95% decrease in the number of viral antigen-containing cells in the warts (p < 0.001). We conclude that warts in EV respond to systemic and intralesional IFN-α.

Original languageEnglish (US)
Pages (from-to)197-202
Number of pages6
JournalJournal of the American Academy of Dermatology
Volume11
Issue number2
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

Fingerprint Dive into the research topics of 'Response of warts in epidermodysplasia verruciformis to treatment with systemic and intralesional alpha interferon'. Together they form a unique fingerprint.

  • Cite this