Response of warts in epidermodysplasia verruciformis to treatment with systemic and intralesional alpha interferon

Elliot Androphy, I. Dvoretzky, A. E. Maluish, H. J. Wallace, D. R. Lowy

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Abstract

The susceptibility of human papillomavirus infection to polyclonal human leukocyte interferon (IFN-α) has been evaluated in patients with epidermodysplasia verruciformis (EV), a disease with extensive chronic papillomavirus-induced warts. In a double-blind, placebo-controlled study with intralesional IFN-α, four of five IFN-α-treated warts regressed; none of the placebo-treated warts responded (p = p.024). Three patients with EV were treated with systemic IFN-α for 4 weeks in an open study, achieving partial regression of warts in all three. In a double-blind, placebo-controlled study, warts in two children with EV regressed with systemic IFN-α while two who received placebo showed no improvement. The lesions recurred following cessation of therapy. At the completion of therapy with IFN-α, histologic normalization was accompanied by a 95% decrease in the number of viral antigen-containing cells in the warts (p <0.001). We conclude that warts in EV respond to systemic and intralesional IFN-α.

Original languageEnglish (US)
Pages (from-to)197-202
Number of pages6
JournalJournal of the American Academy of Dermatology
Volume11
Issue number2 I
DOIs
StatePublished - 1984
Externally publishedYes

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Epidermodysplasia Verruciformis
Warts
Interferon-alpha
Interferons
Placebos
Therapeutics
Papillomavirus Infections
Viral Antigens

ASJC Scopus subject areas

  • Dermatology

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Response of warts in epidermodysplasia verruciformis to treatment with systemic and intralesional alpha interferon. / Androphy, Elliot; Dvoretzky, I.; Maluish, A. E.; Wallace, H. J.; Lowy, D. R.

In: Journal of the American Academy of Dermatology, Vol. 11, No. 2 I, 1984, p. 197-202.

Research output: Contribution to journalArticle

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abstract = "The susceptibility of human papillomavirus infection to polyclonal human leukocyte interferon (IFN-α) has been evaluated in patients with epidermodysplasia verruciformis (EV), a disease with extensive chronic papillomavirus-induced warts. In a double-blind, placebo-controlled study with intralesional IFN-α, four of five IFN-α-treated warts regressed; none of the placebo-treated warts responded (p = p.024). Three patients with EV were treated with systemic IFN-α for 4 weeks in an open study, achieving partial regression of warts in all three. In a double-blind, placebo-controlled study, warts in two children with EV regressed with systemic IFN-α while two who received placebo showed no improvement. The lesions recurred following cessation of therapy. At the completion of therapy with IFN-α, histologic normalization was accompanied by a 95{\%} decrease in the number of viral antigen-containing cells in the warts (p <0.001). We conclude that warts in EV respond to systemic and intralesional IFN-α.",
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AU - Androphy, Elliot

AU - Dvoretzky, I.

AU - Maluish, A. E.

AU - Wallace, H. J.

AU - Lowy, D. R.

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AB - The susceptibility of human papillomavirus infection to polyclonal human leukocyte interferon (IFN-α) has been evaluated in patients with epidermodysplasia verruciformis (EV), a disease with extensive chronic papillomavirus-induced warts. In a double-blind, placebo-controlled study with intralesional IFN-α, four of five IFN-α-treated warts regressed; none of the placebo-treated warts responded (p = p.024). Three patients with EV were treated with systemic IFN-α for 4 weeks in an open study, achieving partial regression of warts in all three. In a double-blind, placebo-controlled study, warts in two children with EV regressed with systemic IFN-α while two who received placebo showed no improvement. The lesions recurred following cessation of therapy. At the completion of therapy with IFN-α, histologic normalization was accompanied by a 95% decrease in the number of viral antigen-containing cells in the warts (p <0.001). We conclude that warts in EV respond to systemic and intralesional IFN-α.

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