Response suppression induced with selective 5-HT agonists can be differentially blocked with LY53857 in an animal model of depression

E. A. Engleman, J. M. Murphy, F. C. Zhou, J. N. Hingtgen

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Studies from this laboratory have demonstrated that administration of the selective 5-HT2/1C antagonist LY53857 can block 5-HTP-induced response suppression. To further investigate the serotonergic mechanisms involved in this effect, we decided to test the capacity of LY53857 to block response suppression induced with two selective 5-HT agonists. After a 15 minute baseline period, rats trained to press a lever for milk reinforcement on a VI 1′ schedule were given IP injections of 1.0 mg/kg DOI, or 1.0 mg/kg 8-OH-DPAT to induce response suppression. Subsequently, rats were injected with 1.0 mg/kg LY53857 1 hour prior to DOI- or 8-OH-DPAT-induced response suppression. Preinjections with LY53857 resulted in a 100% blockade of DOI-induced response suppression whereas the same dose did not block response suppression induced with 8-OH-DPAT. These results indicate that the 5-HTP-induced response suppression shows some pharmacological similarity to DOI-induced response suppression and may be mediated through 5-HT2 and/or 5-HT1C receptors.

Original languageEnglish (US)
Pages (from-to)483-488
Number of pages6
JournalNeurochemical Research
Volume17
Issue number5
DOIs
StatePublished - May 1 1992

Keywords

  • 5-HTP
  • 8-OH-DPAT
  • Behavior
  • depression
  • DOI
  • serotonin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

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